Pitfalls in the accurate measurement of joint space narrowing in semiflexed, anteroposterior radiographic imaging of the knee

Arthritis and Rheumatism
Steven A MazzucaMichel Lequesne

Abstract

Computerized measurement of changes in joint space width (JSW) on serial radiographs of the knee in the semiflexed, anteroposterior (SF-AP) view has been used recently as a primary outcome measure in clinical trials of disease-modifying osteoarthritis drugs (DMOADs). In the use of fluoroscopy to achieve reproducible alignment of the medial tibial plateau and x-ray beam, the SF-AP radiographic protocol affords greater sensitivity in the detection of joint space narrowing (JSN) than that achieved by conventional radiographic positioning techniques. However, the utility of the SF-AP view is compromised by the variation in x-ray penetration in each examination, which may confound the correction of the automated measurement of JSW for the radiographic magnification inherent in an AP view of the knee. A recent DMOAD trial using the SF-AP protocol showed an improbable increase in JSW of > or =0.50 mm (i.e., greater than the measurement error). The present report provides an analysis of this problem, and the study aim was to demonstrate that substitution of the automated estimates of JSW with precise manual measurements can markedly reduce the problem attributable to radiographic magnification. SF-AP radiographs were obtained at baseli...Continue Reading

References

Aug 2, 2003·Aging Clinical and Experimental Research·Olivier BruyèreJean-Yves L Reginster
Dec 1, 1957·Annals of the Rheumatic Diseases·J H KELLGREN, J S LAWRENCE

❮ Previous
Next ❯

Citations

May 26, 2005·Skeletal Radiology·J E SchmidtK R Kaufman
Sep 3, 2010·Annals of Nuclear Medicine·Yusuke UmemotoTomoyuki Saito
Aug 26, 2006·Nature Clinical Practice. Rheumatology·Tim D Spector
Feb 3, 2009·Nature Clinical Practice. Rheumatology·Jean-Pierre Pelletier, Johanne Martel-Pelletier
Feb 8, 2006·Current Opinion in Rheumatology·David J Hunter, Philip G Conaghan
Apr 3, 2009·Current Opinion in Rheumatology·David J HunterFelix Eckstein
Nov 23, 2012·BMC Musculoskeletal Disorders·Shaw-Ruey LyuChih-Wen Lin
May 6, 2014·Best Practice & Research. Clinical Rheumatology·David J HunterVirginia Kraus
Jun 1, 2012·PM & R : the Journal of Injury, Function, and Rehabilitation·David J Hunter, Ali Guermazi
Jun 21, 2011·Lancet·Johannes W J BijlsmaFloris P J G Lafeber
Nov 26, 2009·Rheumatic Diseases Clinics of North America·Marie-Pierre Hellio Le GraverandAlan Brett
Jul 28, 2009·Radiologic Clinics of North America·Marie-Pierre Hellio Le GraverandAlan Brett
Aug 9, 2008·Rheumatic Diseases Clinics of North America·Ali GuermaziFrank W Roemer
Apr 18, 2008·Osteoarthritis and Cartilage·L GossecUNKNOWN OARSI-OMERACT task force "total articular replacement as outcome measure in OA"
Mar 6, 2007·Osteoarthritis and Cartilage·H NakamuraM Beppu
Nov 1, 2006·Osteoarthritis and Cartilage·S Botha-ScheepersM Dougados
Dec 17, 2008·Osteoarthritis and Cartilage·G NeumannUNKNOWN Health ABC Study
Jan 8, 2013·Seminars in Arthritis and Rheumatism·Marie-Pierre Hellio Le GraverandEric Vignon
May 12, 2009·Osteoarthritis and Cartilage·D J Hunter
Nov 1, 2005·Current Therapeutic Research, Clinical and Experimental·Peter GhoshMargaret Smith
Apr 17, 2007·The American Journal of Sports Medicine·Jack FarrKevin M Marberry
Apr 9, 2017·Annals of the Rheumatic Diseases·Garifallia SakellariouAnnamaria Iagnocco
Oct 3, 2006·Arthritis and Rheumatism·Alan E MikeskyKathleen A Lane
Jun 30, 2005·Arthritis and Rheumatism·Paul Dieppe
Aug 28, 2020·Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders·Nuria Muñoz-GarcíaRosario Madero-Jarabo
Feb 13, 2021·Statistics in Medicine·Dulal K BhaumikBikas K Sinha

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.