Pitfalls in the diagnosis of mitochondrial encephalopathy with lactic acidosis and stroke-like episodes

Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society
Iris Ben-Bassat MizrachiJonathan D Trobe

Abstract

We describe a patient with genetically- and biochemically-proven mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS) who was initially misdiagnosed as having had multiple ischemic strokes in part because the clinical presentation appeared to be acute, the MRI of lesions showed restricted diffusion, and the brain biopsy showed features suggestive of stroke. This report emphasizes the pitfalls in the diagnosis of MELAS and points out the similarities and differences between MELAS and ischemic stroke.

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Citations

Oct 16, 2012·Brain : a Journal of Neurology·Charalampos Tzoulis, Laurence A Bindoff
Jul 9, 2010·Brain & Development·Hiromichi ItoShoji Kagami
Feb 20, 2009·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Benjamin OngStephen Stuckey
Jan 6, 2007·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Wenya Linda BiRobert L Lesser
Jul 7, 2018·The Neuroradiology Journal·Josef Finsterer, Sinda Zarrouk-Mahjoub
Jan 14, 2011·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Ji Hye KimChang Hae Shu
Dec 20, 2008·Stroke; a Journal of Cerebral Circulation·Charalampos Tzoulis, Laurence A Bindoff
Apr 22, 2009·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Josef Finsterer

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