Pituitary adenomas in children and young adults

Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
Kara Leigh KrajewskiJörg Flitsch

Abstract

Pituitary adenomas are rare in the pediatric population. We present a recent cohort of children operated transsphenoidally on pituitary adenoma from a single center. Inclusion criteria were age < 21 years and histopathological diagnosis of adenoma after transsphenoidal surgery. The electronic file was used for prospective and retrospective data collection on symptoms, pituitary function before/after surgical intervention, and surgical complications. Surgical reports were used for assessment of resection grade. Follow-up data were collected from outpatient clinical visit and/or correspondence concerning pituitary function and MRI. Among 962 consecutive patients who underwent transsphenoidal surgery at the University Medical Center Hamburg-Eppendorf (Germany) between April 2013-December 2016, 50 patients (5.2%) were 21 years old or younger (range 6-21 years, mean 16.5). Twenty-five (50%) patients had pituitary adenomas; M:F = 13:12. Eight were macroadenomas (> 1cm3). Time from onset of symptoms to first operation had a range of 0-48 months (mean 18.5 months). Nine (36%) patients overall complained of headaches preoperatively. One patient had objective (hemianopsia) and four subjective visual disturbances preoperatively. Histopath...Continue Reading

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Citations

Jan 31, 2021·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Valentina PennacchiettiUlrich Wilhelm Thomale
Jun 18, 2021·Journal of Neuroendocrinology·Emilia SbardellaUNKNOWN Talent group
Aug 19, 2021·Journal of Pediatric Endocrinology & Metabolism : JPEM·Breanna L SheldonMatthew A Adamo

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