Pituitary adenylate cyclase-activating polypeptide maintains neonatal breathing but not metabolism during mild reductions in ambient temperature

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Kevin J CummingsRichard J A Wilson

Abstract

Mild reductions in ambient temperature dramatically increase the mortality of neonatal mice deficient in pituitary adenylate cyclase-activating polypeptide (PACAP), with the majority of animals succumbing in the second postnatal week. During anesthesia-induced hypothermia, PACAP(-/-) mice at this age are also vulnerable to prolonged apneas and sudden death. From these observations, we hypothesized that before the onset of genotype-specific mortality and in the absence of anesthetic, the breathing of PACAP-deficient mice is more susceptible to mild reductions in ambient temperature than wild-type littermates. To test this hypothesis, we recorded breathing in one group of postnatal day 4 PACAP+/+, (+/-), and (-/-) neonates (using unrestrained, flow-through plethysmography) and metabolic rate in a separate group (using indirect calorimetry), both of which were exposed acutely to ambient temperatures slightly below (29 degrees C), slightly above (36 degrees C), or at thermoneutrality (32 degrees C). At 32 degrees C, the breathing frequency of PACAP(-/-) neonates was significantly less than PACAP+/+ littermates. Reducing the ambient temperature to 29 degrees C caused a significant suppression of tidal volume and ventilation in both ...Continue Reading

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Citations

Nov 14, 2013·Neuropeptides·Sanbing ShenDavid A Collier
Jul 6, 2014·Journal of Molecular Neuroscience : MN·Eszter BankiAndras Garami
Apr 20, 2013·Respiratory Physiology & Neurobiology·E V FergusonR J A Wilson
May 18, 2010·Respiratory Physiology & Neurobiology·Melissa M J Farnham, Paul M Pilowsky
Jul 1, 2008·Respiratory Physiology & Neurobiology·Richard J A Wilson, Kevin J Cumming
Sep 19, 2015·Respiratory Physiology & Neurobiology·Mufaddal I BaghdadwalaRichard J A Wilson
Apr 6, 2016·General and Comparative Endocrinology·José Ávila-MendozaCarlos Arámburo
Jul 14, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Karlene T BarrettRichard J A Wilson
Jan 16, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Geeta GodaraJohn Mathai
Apr 19, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Arijit RoyRichard J A Wilson
Feb 14, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Karlene T BarrettRichard J A Wilson
Nov 5, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Karlene T BarrettRichard J A Wilson
Dec 4, 2020·Nature·Yingtang ShiDouglas A Bayliss

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