Pituitary adenylate cyclase-activating polypeptide ameliorates vascular dysfunction induced by hyperglycaemia

Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease
Margit SolymarDora Reglodi

Abstract

Short-lasting hyperglycaemia occurs frequently in prediabetes and poorly controlled diabetes mellitus leading to vascular damage. Pituitary adenylate cyclase-activating polypeptide (PACAP) has been shown to play a protective role in vascular complications of diabetes; moreover, antioxidant effects of PACAP were also described. Therefore, we hypothesized that PACAP exerts protective effects in short-term hyperglycaemia-induced vascular dysfunctions. After short-term hyperglycaemia, acetylcholine-induced and sodium nitroprusside-induced vascular relaxation of mouse carotid arteries were tested with a myograph with or without the presence of PACAP or superoxide dismutase. Potential direct antioxidant superoxide-scavenging action of pituitary adenylate cyclase-activating peptide was tested with pyrogallol autoxidation assay; furthermore, the effect of pituitary adenylate cyclase-activating peptide or superoxide dismutase was investigated on hyperglycaemia-associated vascular markers. PACAP administration resulted in reduced endothelial dysfunction after a 1-h hyperglycaemic episode. PACAP was able to restore acetylcholine-induced relaxation of the vessels and improved sodium nitroprusside-induced relaxation. This effect was compara...Continue Reading

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Citations

Jul 19, 2019·Annals of the New York Academy of Sciences·Eszter FabianIstvan A Krizbai
Sep 6, 2019·Computational and Mathematical Methods in Medicine·Xue LiYanning Fang
Oct 23, 2018·GeroScience·D ReglodiA Bardosi
Aug 9, 2020·Frontiers in Endocrinology·Denes TothDora Reglodi
Jan 7, 2021·Journal of Molecular Neuroscience : MN·Agata Grazia D'AmicoVelia D'Agata
Apr 4, 2021·International Journal of Molecular Sciences·Dora SzaboAndrea Tamas

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Methods Mentioned

BETA
protein array
X-ray

Software Mentioned

Sigma Plot
Image J
Myodaq

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