Pituitary adenylate cyclase-activating polypeptide in the testis of the quail Coturnix coturnix: Expression, localization, and phylogenetic analysis

Evolution & Development
Marina PriscoSalvatore Valiante

Abstract

To evaluate the involvement of pituitary adenylate cyclase-activating polypeptide (PACAP)/receptors system in the control of testis activity, we have investigated the expression and localization of PACAP and the distribution of its receptors in the testis of mature samples of quail Coturnix coturnix, and we have performed a phylogenetic analysis of PACAP in birds. Using histological, molecular, and bioinformatics tools, we demonstrated that (a) PACAP messenger RNA shows a high sequence identity with that reported in other birds studied so far and in other vertebrates. Furthermore, we showed that purifying selection acts on PACAP; (b) the PACAP peptide is present only in Leydig cells, whereas its receptors are localized within both Leydig and germ cells; (c) the synthesis of PACAP does not take place in seminiferous tubules. The role of PACAP in the control of spermatogenesis and steroidogenesis in birds is discussed. Finally, we talk about the phylogenetic and evolutionary relationships between PACAP in birds and in other vertebrates.

References

Oct 16, 1989·Biochemical and Biophysical Research Communications·A MiyataD H Coy
Nov 25, 2004·Journal of Biochemical and Biophysical Methods·Balázs JakabJózsef Németh
Feb 28, 2009·Journal of Anatomy·Yong-Guang GongRen-Shan Ge
May 21, 2009·General and Comparative Endocrinology·Marina PriscoPiero Andreuccetti
Oct 28, 2009·Results and Problems in Cell Differentiation·Jan Fahrenkrug
Mar 17, 2010·Molecular Biology and Evolution·Tong ZhouClaus O Wilke
Oct 15, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zsolt PirgerGyörgy Kemenes
Nov 13, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Ichiro TaniiHideki Fuse
Sep 29, 2011·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Minhua XuErchao Li
May 29, 2012·Protein and Peptide Letters·T Kiss, Z Pirger
Jul 25, 2012·Journal of Molecular Neuroscience : MN·Marisa AgneseMarina Prisco
Oct 18, 2013·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Apr 4, 2014·General and Comparative Endocrinology·Marisa AgnesePiero Andreuccetti
Apr 23, 2014·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Marisa AgneseMarina Prisco
May 24, 2014·General and Comparative Endocrinology·Luigi RosatiMarisa Agnese
Sep 10, 2015·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Luigi RosatiMarisa Agnese
Sep 24, 2015·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Marisa AgneseMarina Prisco
Nov 1, 2015·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Luigi RosatiMarisa Agnese
Aug 5, 2016·The Journal of Experimental Biology·Luigi RosatiMarina Prisco
Jun 29, 2017·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Marina PriscoLuigi Rosati
Aug 9, 2017·Comptes rendus biologies·Luigi RosatiMarina Prisco
Nov 12, 2017·Comptes rendus biologies·Luigi RosatiMarina Prisco

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Citations

May 31, 2019·Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology·Marisa AgnesePiero Andreuccetti
Aug 23, 2019·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Luigi RosatiAlessandra Santillo
Aug 11, 2020·General and Comparative Endocrinology·Luigi RosatiMarina Prisco
May 1, 2021·Animals : an Open Access Journal From MDPI·Mariana Di LorenzoLuigi Rosati
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Sara FalvoAlessandra Santillo
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Luigi RosatiMaria Maddalena Di Fiore

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