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Pituitary Adenylate Cyclase-Activating Polypeptide in the Ventromedial Hypothalamus Is Responsible for Food Intake Behavior by Modulating the Expression of Agouti-Related Peptide in Mice

Molecular Neurobiology

Jan 14, 2020

Thanh Trung NguyenAtsuro Miyata

Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP) is abundantly expressed in the hypothalamus and contributes to hypothalamic functions, including appetite regulation. Although food intake is suggested to be decreased in PACAP (-/-) mice, the detailed mechanisms are still being...read more

Mentioned in this Paper

Hypothalamic Structure
Administration Procedure
Anti-Obesity Agents
Protein Overexpression
Fasting
Modulated
Refeeding Syndrome
Appetite Regulation
Peptides
Pituitary Adenylate Cyclase-Activating Polypeptide Receptors
1
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Pituitary Adenylate Cyclase-Activating Polypeptide in the Ventromedial Hypothalamus Is Responsible for Food Intake Behavior by Modulating the Expression of Agouti-Related Peptide in Mice

Molecular Neurobiology

Jan 14, 2020

Thanh Trung NguyenAtsuro Miyata

PMID: 31927724

DOI: 10.1007/s12035-019-01864-7

Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP) is abundantly expressed in the hypothalamus and contributes to hypothalamic functions, including appetite regulation. Although food intake is suggested to be decreased in PACAP (-/-) mice, the detailed mechanisms are still being...read more

Mentioned in this Paper

Hypothalamic Structure
Administration Procedure
Anti-Obesity Agents
Protein Overexpression
Fasting
Modulated
Refeeding Syndrome
Appetite Regulation
Peptides
Pituitary Adenylate Cyclase-Activating Polypeptide Receptors
1

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The innate immune system is a first line of defense against infection. Pathological states can occur if there is over activation of the innate immune system, particularly in the. The excessive activation of these cells can lead to inflammation and neurodegenerative diseases. Here is the latest research on innate immunity and neurodegeneration.

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Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology

Pituitary adenylate cyclase-activating polypeptide inhibits food intake in mice through activation of the hypothalamic melanocortin system

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