PMID: 8993404Dec 26, 1996Paper

Pituitary adenylate cyclase-activating polypeptides, PACAP-38 and PACAP-27, regulation of sympathetic neuron catecholamine, and neuropeptide Y expression through activation of type I PACAP/VIP receptor isoforms

Annals of the New York Academy of Sciences
K M Braas, V May

Abstract

The current studies have implicated a prominent role for PACAP peptides in modulating the physiological function of cells derived from the sympathoadrenal lineage. Compared to VIP, both PACAP-27 and PACAP-38 demonstrated potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. The differential effects of PACAP peptides on SCG NPY and catecholamine content and secretion coincided with previous studies that activated directly the sympathetic intracellular cyclic AMP-protein kinase A signaling pathway. These effects appear to be mediated primarily by PACAP1 receptor splice variants coupled to both adenylyl cyclase and phospholipase C in SCG neurons. The actions of PACAP peptides in the SCG shared many parallels with adrenal medullary chromaffin cells, suggesting diverse roles for the PACAP peptidergic system in sympathoadrenal cell development and function. Rather than solutions, these results pose additional questions for the future. What are the endogenous sources of PACAP that regulate sympathetic and adrenal function? Do PACAP peptides, like VIP, have dual roles and also act as sympathetic postganglionic neuromodulators? Are VIP/PACAP receptors expressed during SCG develo...Continue Reading

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Citations

May 6, 2016·Journal of Molecular Neuroscience : MN·Beatrice M GirardMargaret A Vizzard
May 8, 2010·Journal of Molecular Neuroscience : MN·Beatrice M GirardMargaret A Vizzard
Dec 3, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Karen M BraasMargaret A Vizzard
Dec 20, 2017·Frontiers in Systems Neuroscience·Beatrice M GirardMargaret A Vizzard
Sep 28, 2018·Journal of Molecular Neuroscience : MN·Jacqueline OjalaMargaret A Vizzard
Feb 24, 2001·Annals of the New York Academy of Sciences·V MayK M Braas
Aug 3, 2007·Journal of Neuroscience Research·Khalid M KhanDennis G Drescher
May 23, 2012·Journal of Molecular Neuroscience : MN·Corey B Smith, Lee E Eiden
Oct 2, 2017·Pflügers Archiv : European journal of physiology·Lee E EidenCorey B Smith
Nov 15, 1997·The American Journal of Physiology·G GengN Yamaguchi
Jul 20, 2018·Journal of Molecular Neuroscience : MN·Thomas J HeppnerMargaret A Vizzard

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