Pituitary carcinoma recurrent to the lumbar intradural extramedullary space: case report.

The Journal of Spinal Cord Medicine
Paul M ArnoldPhilip L Johnson

Abstract

Pituitary tumors are rare, and pituitary carcinomas are rarer still. Prognosis is poor, with less than 50% of patients surviving past 1 year after diagnosis. In this case of spinal metastasis from an adrenocorticotropic hormone-secreting pituitary carcinoma, the intradural extramedullary metastases recurred in the same lumbar area 6 years apart. Fourteen years prior to presentation in our clinic, a 48-year-old woman was diagnosed with pituitary adenoma which was treated with resection followed by radiation. Eight years later, an intradural extramedullary spinal drop metastasis at L2-L3 was again treated with resection and radiation. Three years later, magnetic resonance imaging (MRI) revealed a mass encasing the right carotid artery, which was treated for 1 year with chemotherapy using temozolomide (Temodar). Three years later, MRI showed intradural extramedullary metastases at the L3-L4 intervertebral disc space and behind the L3 vertebral body; treatment was again resection followed by radiation. Back pain and weakness resolved after surgery and her neurological examination returned to baseline. There was no evidence of recurrence 1 year after surgery. In this unusual case, this pituitary carcinoma metastasized twice in 6 yea...Continue Reading

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Citations

Aug 21, 2013·Medical Molecular Morphology·Akira MatsunoR Yoshiyuki Osamura
Dec 3, 2014·Neurologia Medico-chirurgica·Toshio HirohataAkira Matsuno
Jun 25, 2015·International Journal of Endocrinology·Oscar D BrunoReynaldo M Gómez
Mar 17, 2015·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·James K LiuJean Anderson Eloy
Oct 22, 2019·Spinal Cord Series and Cases·Charles F LandJohn G DeVine
Jun 6, 2020·Reviews in Endocrine & Metabolic Disorders·Michael Buchfelder, Sven-Martin Schlaffer
May 8, 2020·Spinal Cord Series and Cases·Charles F LandJohn G DeVine
Jul 6, 2021·Frontiers in Endocrinology·Masaaki YamamotoHidenori Fukuoka

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