PMID: 8605573Mar 1, 1996Paper

Pituitary choristoma composed of corticotrophs and adrenocortical cells in the sella turcica

Virchows Archiv : an International Journal of Pathology
H OkaK Yada

Abstract

A pituitary tumour composed of well-differentiated corticotrophs and adrenocortical cells is reported. Sections of the tumour revealed a mixture of small round cells with amphophilic or basophilic periodic acid-Schiff (PAS)-positive cytoplasm and large spherical and oval cells with abundant, granular, partly vacuolated PAS-negative cytoplasm. The small cells contained type 1 cytokeratin-positive microfilaments, numerous 250-500 nm endocrine-type secretory granules immunoreactive for adenocorticotropic hormone (ACTH) and beta-lipotropin. The large cells possessed ample cytoplasm filled with abundant vesicular smooth endoplasmic reticulum, numerous mitochondria possessing tubulovesicular cristae and frequent dense bodies. They lacked the features of pituitary endocrine cells or folliculostellate cells and were found to contain a panel of steroidogenic dehydrogenases and hydroxylases. The tumour was classified as a choristoma, in which two distinct cells types, corticotrophs and adrenocortical cells, were mixed. We suggest that, under continued ACTH stimulation, umcommitted stem cells may differentiate into adrenocortical cells. Alternatively, the presence of adrenocortical cells may be the result of heterotopia.

Citations

Oct 23, 2008·The American Journal of Surgical Pathology·Fausto J RodriguezCaterina Giannini
Jan 1, 2007·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Masamitsu Futai
Jan 9, 2020·Reviews in Endocrine & Metabolic Disorders·Christina Tatsi, Constantine A Stratakis
Aug 10, 2002·The American Journal of Surgical Pathology·Federico RoncaroliAllan J Yates
Aug 19, 2018·Der Pathologe·W Saeger

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