Pituitary desensitization to gonadotropin-releasing hormone increases abdominal adiposity in hyperandrogenic anovulatory women

Fertility and Sterility
D DumesicM D Jensen

Abstract

To determine whether hyperandrogenism in anovulatory women affects body fat distribution. Prospective nonrandomized study. An academic research environment. Ten hyperandrogenic anovulatory patients and 10 healthy women matched by body mass index. Regional body fat analysis was performed before and after 3 months of GnRH analogue (GnRH-a) therapy. Body fat distribution was measured by waist-to-hip circumference ratio, single-slice computed tomography imaging (L2-3 interspace), and total body dual-energy x-ray absorptiometry. Weight, body mass index, waist-to-hip circumference ratio, total body and leg fat mass, and subcutaneous adipose area were unaffected by the presence of hyperandrogenism or the use of GnRH-a therapy. Basal abdominal fat mass, abdomen-to-leg fat mass ratio, visceral adipose area, and total visceral adipose volume were comparable in both study groups. The abdominal fat mass increased in both groups during GnRH-a therapy, whereas the abdomen-to-leg fat mass ratio rose significantly only in the hyperandrogenic patients. During GnRH-a therapy, the hyperandrogenic patients demonstrated a significant increase in visceral adipose area compared with the healthy women so that total visceral adipose volume increased si...Continue Reading

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Citations

Mar 10, 2001·Obstetrics and Gynecology·H YamasakiY Nagata
May 7, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S Franks
Mar 13, 2009·Human Reproduction·Roy Homburg
Jan 10, 2014·The Journal of Nutrition, Health & Aging·M RondanelliM Grassi
May 2, 2006·Fertility and Sterility·Renato Pasquali
Jan 17, 2008·Gynecologic and Obstetric Investigation·Fatma Ferda Verit, Ozcan Erel
Jun 25, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A GambineriR Pasquali
Sep 5, 2015·Journal of Applied Physiology·Edward L MelansonWendy M Kohrt
Jun 6, 2003·The Journal of Clinical Endocrinology and Metabolism·Lourdes IbáñezFrancis de Zegher
Mar 19, 2015·Menopause : the Journal of the North American Menopause Society·Karen L SheaWendy M Kohrt

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