PMID: 8961133Sep 1, 1996Paper

Pituitary enlargement due to primary hypothyroidism: growth hormone response to GHRH, GHRP-6 and GHRH plus GHRP-6

Journal of Pediatric Endocrinology & Metabolism : JPEM
S DamjanovicF F Casanueva

Abstract

GH secretion after growth hormone-releasing hormone (GHRH), growth hormone releasing peptide-6 (GHRP-6) and after combined administration of both peptides was studied in a patient with lactotrope and thyrotrope hyperplasia due to primary hypothyroidism. Pituitary pseudotumor disappeared after thyroid hormone replacement; this was evidenced by magnetic resonance imaging (NMR). There was no difference between areas under the curve (AUCzero-120 min) during GHRH test before and after thyroid hormone replacement (136.5 vs 129.0 micrograms/l min). Maximal GH increases over basal values (delta GH) did not change (1.5 and 1.9 micrograms/l). GH secretion induced by GHRP-6 increased after treatment (AUCzero-120 min 197.2 vs 650.4 micrograms/l min). delta GH increments were 4.0 and 18.3 micrograms/l before and after therapy respectively. When the peptides were administered together a synergistic effect on GH secretion was observed but GH release was much more powerful after pituitary pseudotumor disappearance (AUCzero-120 min 1043.2 vs 2046.7 micrograms/l min). This was accompanied by increased delta GH (22.7 vs 35.5 micrograms/l). The synergic action of peptides normalized in euthyroid condition and after the resolution of pituitary pseu...Continue Reading

References

Apr 1, 1991·Endocrinology·C Y BowersT M Badger
Apr 1, 1990·The Journal of Clinical Endocrinology and Metabolism·C Y BowersM O Thorner
Feb 1, 1986·The Journal of Clinical Endocrinology and Metabolism·A E SmalsP W Kloppenborg
Sep 1, 1985·The Journal of Clinical Endocrinology and Metabolism·T WilliamsL A Frohman

❮ Previous
Next ❯

Citations

Jan 7, 2021·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Shabal SapkotaSulav Sapkota

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.