Pituitary enlargement in patients with primary hypothyroidism.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Nahla M KhawajaKamel M Ajlouni

Abstract

To assesses the frequency and degree of pituitary hyperplasia in patients with primary hypothyroidism, the association of pituitary enlargement with disease severity, and the response to treatment. Between April 2002 and August 2004 at the National Center for Diabetes, Endocrinology and Genetics in Amman, Jordan, 53 patients (49 female and 4 male subjects) with primary hypothyroidism and serum thyrotropin (thyroid-stimulating hormone or TSH) levels of > or = 50 microIU/mL were encountered. Initial and follow-up investigations included thyroid function tests, serum prolactin levels, and magnetic resonance imaging (MRI) of the pituitary. Visual field examination was requested for all patients with pituitary enlargement (and adequately completed in 24). Pituitary enlargement on MRI was found in 37 of the 53 patients (70%), with 31 of the 37 patients (84%) having TSH levels of > or = 100 microIU/mL. After thyroxine treatment, 85% of the patients with pituitary enlargement who underwent a follow-up MRI showed a decrease in size of the gland. About half of the patients were referred to our facility with the diagnosis of hypothyroidism; presenting features in the rest of the patients included galactorrhea, menstrual irregularities, le...Continue Reading

References

Dec 1, 1976·The Journal of Clinical Endocrinology and Metabolism·A M Mroueh, T M Siler-Khodr
May 1, 1976·The Journal of Clinical Endocrinology and Metabolism·T YamadaM Kotani
Aug 1, 1983·The Journal of Clinical Endocrinology and Metabolism·K YamamotoS Yoshida
Jun 1, 1996·Archives of Pediatrics & Adolescent Medicine·M P DesaiM P Colaco
Mar 1, 1997·The Journal of Clinical Endocrinology and Metabolism·N J SarlisM C Skarulis
Jan 5, 2000·British Journal of Neurosurgery·M YoungK Gupta
Mar 23, 2000·Postgraduate Medical Journal·M Brändle, C Schmid
Dec 23, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Bassam M TaherKamel M Ajlouni
Sep 24, 2004·European Journal of Clinical Investigation·B M TaherK M Ajlouni

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Citations

Oct 14, 2009·Clinical and Experimental Medicine·Rogelio García-CentenoAntonino Jara-Albarrán
Dec 4, 2012·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Brent L FinleyDennis J Paustenbach
Apr 9, 2011·Italian Journal of Pediatrics·Roberto FranceschiAnnunziata Di Palma
Dec 14, 2011·Journal of Endocrinological Investigation·P Iglesias, J J Díez
Mar 21, 2016·Clinical Imaging·Mark D MamloukErin F Mathes
May 8, 2013·Journal of Paediatrics and Child Health·Nicholas J W MillsJacqueline K Hewitt
Aug 19, 2015·Endocrinology, Diabetes & Metabolism Case Reports·C P NevesW W de Herder
May 8, 2016·World Neurosurgery·Rahim KhorassanizadehSteven N Levine
May 3, 2011·Journal of Neurosurgery. Pediatrics·Kristian Aquilina, Frederick A Boop
Oct 24, 2018·Endocrine Connections·Lijin JiBin Lu
Sep 28, 2013·Indian Journal of Pediatrics·Rajendra Prasad NamburiAmaresh Reddy Ponnala
Aug 2, 2011·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Alyson MyersIldiko Lingvay
Aug 1, 2020·Frontiers in Endocrinology·Anna Małgorzata KucharskaMałgorzata Rumińska
Apr 3, 2020·Pediatrics in Review·Rebecca SteuartLisa E Herrmann
Jan 1, 2015·Global Pediatric Health·Yonatan YeshayahuGal Dubnov-Raz
Jul 26, 2019·Case Reports in Endocrinology·Prateek ShuklaPooja Luthra
Dec 20, 2020·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·W ZhuR Han
Dec 30, 2020·BMJ Case Reports·Aparna SharmaVatsla Dadhwal
May 1, 2021·Journal of the Endocrine Society·Juanita K HodaxJose Bernardo Quintos
Nov 14, 2018·Pediatric Emergency Care·Lisa SchwartzTommy Kim
Aug 27, 2021·Case Reports in Pediatrics·Silvia CianciaLorenzo Iughetti

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