Pituitary gland function after disconnection from direct hypothalamic influences in the sheep

Neuroendocrinology
I J ClarkeD M de Kretser

Abstract

A surgical procedure is described for isolating the pituitary gland from hypothalamic influences in sheep. The procedure results in total deafferentation of the stalk and median eminence but maintains the blood supply to the pituitary gland. The median eminence, pituitary stalk and anterior face of the pituitary gland were exposed by a transnasal, transphenoidal approach. In early studies section of the pituitary stalk as close as possible to the pituitary gland caused almost total infarction of the gland. Attempts were made to disconnect the pituitary gland from the hypothalamus by section immediately above the lateral inputs of the superior hypophyseal arteries but variable results were obtained, always with infarction of part of the pars distalis. When the pituitary gland was disconnected from the hypothalamus by entering the median eminence above the portal circulation and evacuating the nervous tissue of the tuber cinereum, (hypothalamo-pituitary disconnection; HPD), a small area of infarction was found in the pars distalis of only 1/10 cases. HPD effectively disconnected the pituitary gland from hypothalamic control whilst the pars distalis was not deprived of its blood supply. Complete severance of hypothalamo-pituitary ...Continue Reading

Citations

Mar 6, 2007·Reviews in Endocrine & Metabolic Disorders·J T Smith, I J Clarke
Jan 1, 1989·Domestic Animal Endocrinology·I J Clarke
Jul 23, 1998·Domestic Animal Endocrinology·D McWilliamsM E Wise
Nov 25, 1998·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·G A Lincoln, M Richardson
Jun 1, 1990·Baillière's Clinical Endocrinology and Metabolism·D L HealyD De Kretser
Jun 18, 1998·Annals of the New York Academy of Sciences·E RedeiF Aird
Apr 2, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·M AmstaldenG L Williams
Mar 15, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Clay A LentsJ Joe Ford
Jan 1, 1993·Acta neurochirurgica·K AritaT Mikami
Apr 24, 2013·Animal Science Journal = Nihon Chikusan Gakkaihō·Hiroaki OkamuraYoshihiro Wakabayashi
May 11, 2010·Frontiers in Neuroendocrinology·Stuart P BlissMark S Roberson
Feb 3, 2009·Domestic Animal Endocrinology·B N PierceA J Tilbrook
Feb 27, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ralf OheimPia Pogoda
Jan 12, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Frank Timo BeilPia Pogoda
Oct 10, 2013·Clinical Oral Implants Research·Ralf OheimPia Pogoda
Oct 24, 2006·Animal Reproduction Science·J Alejandro Arreguin-ArevaloColin M Clay
Jun 24, 2015·The Journal of Endocrinology·Jonathan D Johnston, Debra J Skene

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