Pituitary-gonadal hormones and adrenal androgens in non-cirrhotic female alcoholics after cessation of alcohol intake

European Journal of Clinical Investigation
M VälimäkiR Ylikahri

Abstract

To investigate the sex-hormone profiles associated with chronic alcoholism in women we examined 16 non-cirrhotic alcohol abusers (aged 18-46 years). They were admitted for the treatment of alcoholism (duration of 2-16 yrs) to a social hospital for 6 weeks. Their mean daily alcohol consumption was 170 g. Blood samples for serum LH, FSH, prolactin (PRL), oestrone (E1), oestradiol (E2), progesterone (P), 17-alpha-hydroxyprogesterone (17-OHP), androstenedione (A) and dehydroepiandrosterone (DHEA) were drawn three times a week during the hospital stay. Similar blood samples were taken from 10 control women during one menstrual cycle. The cycles were anovulatory in two patients and in none of controls. Serum LH and FSH levels were similar in alcoholic and control women but serum concentrations of PRL were increased 2-4-fold in alcoholic women. In the patients serum, concentrations of E1 and E2 tended to be lower during the follicular and midcycle phases, as did those of P and 17-OHP during the luteal phase. Compared with the controls, serum levels of A were increased 2-3-fold in the patients. A parallel difference between the two groups was seen in serum DHEA concentrations. We conclude that until liver injury, even heavy alcohol dri...Continue Reading

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Citations

Sep 22, 2001·The Journal of Steroid Biochemistry and Molecular Biology·T SarkolaC J Eriksson
Sep 10, 2013·Endocrinology and Metabolism Clinics of North America·Nadia Rachdaoui, Dipak K Sarkar
Jan 15, 1996·Biological Psychiatry·A Johansson, B Mowry
Aug 16, 2016·Alcohol·Annemarie HeberleinThomas Hillemacher
Nov 24, 2007·Alcoholism, Clinical and Experimental Research·Dipak K Sarkar, Nadka I Boyadjieva
Jun 8, 2001·Alcoholism, Clinical and Experimental Research·D K SarkarK W Singletary
Nov 24, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shuet Fong NeongStephen E Congly
Mar 14, 2020·Reproductive Biology and Endocrinology : RB&E·Cristina de AngelisRosario Pivonello

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