PMID: 9184631Jun 1, 1997Paper

Pituitary hormones modulate cell-cell interactions between thymocytes and thymic epithelial cells

Journal of Neuroimmunology
Valéria de Mello-CoelhoW Savino

Abstract

The thymic microenvironment plays a key role in the intrathymic T-cell differentiation. It is composed of a tridimensional network of epithelial cells whose physiology is controlled by extrinsic circuits such as neuroendocrine axes. Herein we show that the expression of extracellular matrix ligands and receptor by cultured thymic epithelial cells is upregulated by prolactin (PRL) and growth hormone (GH), the latter apparently occurring via insulin-like growth factor I (IGF-I). Thymocyte release from the lymphoepithelial complexes, thymic nurse cells, as well as the reconstitution of these complexes are enhanced by PRL, GH or IGF-I. Treatment of a mouse thymic epithelial cell line with these hormones induced an increase in thymocyte adhesion, an effect significantly prevented in the presence of antibodies to fibronectin, laminin or respective receptors VLA-5 and VLA-6. Our data suggest that the in vitro changes in thymocyte/thymic epithelial cell interactions induced by pituitary hormones are partially mediated by the enhancement of extracellular matrix ligands and receptors.

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Citations

Jul 10, 1998·Veterinary Immunology and Immunopathology·N R CoxH J Baker
Apr 27, 2002·Scandinavian Journal of Immunology·W SavinoM Dardenne
Jun 18, 1998·Annals of the New York Academy of Sciences·W SavinoM Dardenne
Jan 18, 2003·The Journal of Clinical Investigation·Elena PeevaBetty Diamond
Nov 15, 2012·Journal of Translational Medicine·Juan E Puche, Inma Castilla-Cortázar
Apr 1, 2005·Radiation Research·Yasuhiro AdachiTetsuo Fukumoto
Oct 7, 2015·Nature Reviews. Endocrinology·Wilson SavinoMireille Dardenne
Dec 5, 2015·Frontiers in Immunology·Wilson SavinoVinicius Cotta-de-Almeida
Jul 25, 2012·Annals of the New York Academy of Sciences·Wilson SavinoMireille Dardenne
Jun 26, 2007·Scandinavian Journal of Immunology·M M Ribeiro-CarvalhoW Savino
Jun 26, 2007·Scandinavian Journal of Immunology·M M Ribeiro-CarvalhoV Mello-Coelho
Nov 30, 2006·Annals of the New York Academy of Sciences·Maria Carlsén, Corrado M Cilio
Aug 2, 2007·Expert Opinion on Biological Therapy·Bela Bodey
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Mar 17, 2004·Journal of Leukocyte Biology·Wilson SavinoDéa Maria Serra Villa-Verde
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Aug 15, 2000·Journal of Cellular Physiology·C C WerneckP A Mourão
Mar 28, 2001·Annals of the New York Academy of Sciences·W SavinoM Dardenne
Jun 18, 1998·Annals of the New York Academy of Sciences·M DardenneM C Postel-Vinay
Apr 12, 2019·European Journal of Pharmacology·Adriana Ribeiro SilvaVinicius de Frias Carvalho
May 25, 2021·Growth Factors·Marvin Paulo LinsMaria Danielma Dos Santos Reis
Feb 16, 2005·Journal of Neuroimmunology·Irena P ZivkovićMileva V Mićić

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