PMID: 9429857Jan 16, 1998Paper

Pituitary incidentalomas

Endocrinology and Metabolism Clinics of North America
M E Molitch

Abstract

Incidental pituitary masses are commonly found during CT and MR imaging performed for a variety of reasons. Screening for hormone oversecretion by these tumors seems to be warranted. Patients with lesions greater than 1 cm should be screened for hypopituitarism. In the absence of visual field abnormalities or hypothalamic/stalk compression, it may be appropriate to observe such patients carefully with repeated MR imaging scans. A limited amount of data suggest that significant tumor enlargement occurs in less than 5% of patients with lesions smaller than 1 cm in diameter. However, all macroadenomas must start out as microadenomas, and thus periodic follow-up is indicated to assess for this possibility. Lesions larger than 1 cm in diameter by their very existence at the time of detection have already indicated a propensity for growth. Significant tumor growth occurs in just over one-quarter of such patients. Hemorrhage into such tumors is uncommon, but anticoagulation may predispose to this complication. When there is no evidence of visual field deficits, an attempt at medical therapy with a dopamine agonist or octreotide is reasonable, realizing that only 10% of such patients will respond with a decrease in tumor size. Alternat...Continue Reading

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Citations

Sep 21, 2013·Pituitary·George A Scangas, Edward R Laws
Apr 20, 1999·Endocrinology and Metabolism Clinics of North America·M E Molitch
Sep 27, 2001·Endocrinology and Metabolism Clinics of North America·M E Molitch
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Jan 23, 1999·Current Opinion in Oncology·E VeznedarogluD W Andrews
Apr 8, 2011·The Journal of Clinical Endocrinology and Metabolism·Pouyan FaminiShlomo Melmed
Jun 23, 2009·Journal of Endocrinological Investigation·D BerkerN Kamel
Feb 16, 2005·Reviews in Endocrine & Metabolic Disorders·Susan Sam, Mark E Molitch
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Sep 29, 2006·Expert Review of Anticancer Therapy·Mark E Molitch
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Jan 30, 2008·Endocrinology and Metabolism Clinics of North America·Andy Levy

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