Pituitary Medicine From Discovery to Patient-Focused Outcomes

The Journal of Clinical Endocrinology and Metabolism
S Melmed

Abstract

This perspective traces a pipeline of discovery in pituitary medicine over the past 75 years. To place in context past advances and predict future changes in understanding pituitary pathophysiology and clinical care. Author's perspective on reports of pituitary advances in the published literature. Clinical and translational Endocrinology. Discovery of the hypothalamic-pituitary axis and mechanisms for pituitary control, have culminated in exquisite understanding of anterior pituitary cell function and dysfunction. Challenges facing the discipline include fundamental understanding of pituitary adenoma pathogenesis leading to more effective treatments of inexorably growing and debilitating hormone secreting pituitary tumors as well as medical management of non-secreting pituitary adenomas. Newly emerging pituitary syndromes include those associated with immune-targeted cancer therapies and head trauma. Novel diagnostic techniques including imaging genomic, proteomic, and biochemical analyses will yield further knowledge to enable diagnosis of heretofore cryptic syndromes, as well as sub classifications of pituitary syndromes for personalized treatment approaches. Cost effective personalized approaches to precision therapy must d...Continue Reading

Citations

Jul 26, 2016·Frontiers in Endocrinology·Cheryl L Bell, Sandra A Murray
Jan 7, 2018·Pituitary·Fabienne LangloisMaria Fleseriu
Jul 25, 2017·Endocrine-related Cancer·Patrick PetrossiansAlbert Beckers
Oct 20, 2018·Nuclear Medicine Communications·Vladimir R VukomanovicAleksandar Djukic
Oct 14, 2019·The Journal of Clinical Endocrinology and Metabolism·Andrea GiustinaShlomo Melmed
Aug 6, 2020·The Journal of Clinical Endocrinology and Metabolism·Vivien BonertShlomo Melmed
Apr 26, 2017·Proceedings of the National Academy of Sciences of the United States of America·Shlomo Melmed
Mar 23, 2019·Nature Reviews. Disease Primers·Annamaria ColaoRosario Pivonello
Jul 28, 2018·Nature Reviews. Endocrinology·Shlomo MelmedAndrea Giustina
Sep 1, 2019·Neurosurgery Clinics of North America·Claire M FaltermeierManish K Aghi
May 25, 2021·Journal of Neurological Surgery. Part B, Skull Base·Jessica W GraysonRichard J Harvey
Mar 12, 2021·The Journal of Clinical Endocrinology and Metabolism·Friso de VriesNienke R Biermasz
Aug 16, 2017·Endocrinología, Diabetes Y Nutrición·Moises MercadoDalia Cuenca

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