Pituitary melanotrope cells of Xenopus laevis are of neural ridge origin and do not require induction by the infundibulum

General and Comparative Endocrinology
G W EaglesonB G Jenks

Abstract

Classical studies in amphibians have concluded that the endocrine pituitary and pars intermedia are derived from epithelial buccal epidermis and do not require the infundibulum for their induction. These studies also assumed that the pituitary is not subsequently determined by infundibular induction. Our extirpation, auto-transplantation and immunohistochemical studies with Xenopus laevis were initiated to investigate early presumptive pituitary development. These studies were conducted especially with reference to the pars intermedia melanotrope cell's induction, and its production and release of α-melanophore stimulating hormone (α-MSH) from the precursor protein proopiomelanocortin (POMC). Auto-transplantation studies demonstrated that the pituitary POMC-producing cells are determined at a stage prior to pituitary-infundibular contact. The results of experiments involving the extirpation of the presumptive infundibulum also indicated that the infundibulum is not essential for the differentiation of POMC-producing cells. We also demonstrated that early pituitary development involves adherence to the prechiasmatic area of the diencephalon with the pituitary placode growing in a posterior direction toward the infundibulum where...Continue Reading

References

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Citations

Mar 27, 2017·Biology Methods and Protocols·Andjin SiegenthalerChiara Benvenuto
Jan 2, 2021·Molecular and Cellular Endocrinology·Sakae KikuyamaReiko Okada

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