PMID: 6538682Jan 1, 1984Paper

Pituitary opioid involvement in ECS-postictal electrogenesis and behavioral depression in rats

Peptides
F C TortellaJ W Holaday

Abstract

The role of pituitary opioids in electroconvulsive shock (ECS)-induced postictal electrogenesis and behavioral depression was investigated in sham-hypophysectomized and hypophysectomized rats. These animals were divided into two subgroups and injected SC with either saline or naloxone (3 mg/kg) 10 min prior to transauricular ECS. Sham-hypophysectomized rats given saline responded to a single ECS with a 65 +/- 18% (s.e.) increase in postictal electrogenesis and a behavioral depression lasting 3840 +/- 530 sec. Naloxone significantly antagonized both the postictal increase in EEG voltage output and behavioral depression. Hypophysectomy by itself was without effect on EEG patterns and only partially attenuated the ECS-induced electrogenesis and postictal depression (31.9 +/- 9% and 2360 +/- 511 sec, respectively). However, in hypophysectomized rats, naloxone did not further antagonize these effects of ECS. Thus, it appears that pituitary opioids may, at least in part, mediate postictal electrogenesis and behavioral depression. Alternatively, since hypophysectomy only partially attenuates these phenomena, central or nonpituitary opioid peptide systems may be involved. In view of the observed decrease in responsiveness to naloxone i...Continue Reading

References

Jan 1, 1977·Experimental Eye Research·M W Brightman
Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J RossierR Guillemin
Jun 6, 1983·Life Sciences·G Meisenberg, W H Simmons
Nov 15, 1982·Life Sciences·F C Tortella, A Cowan
Jan 1, 1981·Neuroscience Letters·O VindrolaA Fernández-Guardiola
Dec 3, 1981·European Journal of Pharmacology·F C TortellaJ W Holaday
Dec 31, 1938·British Medical Journal

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Citations

Jul 1, 1985·Peptides·G A OlsonA J Kastin
Jan 1, 1986·Progress in Neuro-psychopharmacology & Biological Psychiatry·P Kragh-SørensenK Steffensen
Mar 1, 1988·Biological Psychiatry·A M GhadirianN P Nair
Jan 1, 1986·Annals of the New York Academy of Sciences·J W HoladayR J Hitzemann
Oct 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·A PitkänenP Riekkinen
Jan 1, 1986·Annals of the New York Academy of Sciences·J W HoladayR J Hitzemann

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