PMID: 3698189Apr 1, 1986Paper

Pituitary regulation of cytochrome P-450-mediated metabolism of steroids and xenobiotics in rat liver microsomes

Carcinogenesis
A BlanckJ A Gustafsson

Abstract

In a previous paper we reported on the influence of sex and pituitary hormones on the selection of diethylnitrosamine-initiated, enzyme-altered cells by 0.02% (w/w) 2-acetylaminofluorene (2-AAF) and partial hepatectomy in the resistant hepatocyte model (RH-model). The islands of enzyme-altered cells in this model grew faster in male than in female rat liver and the growth rate was markedly decreased in male rats bearing ectopic pituitary grafts during the 2-AAF selection period. Male rats are also generally more susceptible to 2-AAF carcinogenesis than female rats. In order to investigate whether the sex differentiated response to 2-AAF selection and 2-AAF carcinogenesis might be due to pituitary control of xenobiotic metabolism, as previously shown for rat liver metabolism of steroid hormones, we have studied the influence of age, sex and pituitary hormones on the cytochrome P-450-mediated hydroxylations of 2-AAF and benzo[a]pyrene (B[a]P), O-deethylation of 7-ethoxyresorufin and the metabolism of 4-androstene-3,17-dione (androstenedione) in rat liver microsomes. Microsomes from prepubertal rats had a generally higher capacity to metabolize the xenobiotic compounds whereas the capacity for androstenedione hydroxylation was low...Continue Reading

Citations

Aug 21, 1996·Biochimica Et Biophysica Acta·J SakuraiN Nemoto
Nov 1, 1988·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G M AlinkJ H Koeman
Dec 1, 1988·Molecular and Cellular Endocrinology·J M MathisR A Prough
Jan 22, 1990·Molecular and Cellular Endocrinology·L A Haldosén, J A Gustafsson
Jan 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·A Rane, B Ask
Jun 1, 1990·Biochemical Pharmacology·A BlanckA Rane
Feb 14, 1991·European Journal of Biochemistry·V KobliakovL Rossi

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