Pituitary responsiveness to GH-releasing hormone, GH-releasing peptide-2 and thyrotrophin-releasing hormone in critical illness

Clinical Endocrinology
G van den BergheR Bouillon

Abstract

Protein hypercatabolism and preservation of fat depots are hallmarks of critical illness, which is associated with blunted pulsatile GH secretion and low circulating IGF-I, TSH, T4 and T3. Repetitive TRH administration is known to reactivate the pituitary-thyroid axis and to evoke paradoxical GH release in critical illness. We further explored the hypothalamic-pituitary function in critical illness by examining the effects of GH-releasing hormone (GHRH) and/or GH-releasing peptide-2 (GHRP-2) and TRH administration. Critically ill adults (n = 40; mean age 55 years) received two i.v. boluses with a 6-hour interval (0900 and 1500 h) within a cross-over design. Patients were randomized to receive consecutively placebo and GHRP-2 (n = 10), GHRH and GHRP-2 (n = 10), GHRP-2 and GHRH+GHRP-2 (n = 10), GHRH+GHRP-2 and GHRH+GHRP-2 + TRH (n = 10). The GHRH and GHRP-2 doses were 1 microgram/kg and the TRH dose was 200 micrograms. Blood samples were obtained before and 20, 40, 60 and 120 minutes after each injection. Serum concentrations of GH, T4, T3, rT3, thyroid hormone binding globulin (TBG), IGF-I, insulin and cortisol were measured by RIA; PRL and TSH concentrations were determined by IRMA. Critically ill patients presented a striking ...Continue Reading

Citations

Oct 17, 2002·Frontiers in Neuroendocrinology·Greet Van den Berghe
Mar 25, 1999·Burns : Journal of the International Society for Burn Injuries·G H Van den Berghe
Sep 18, 2004·The Proceedings of the Nutrition Society·Frank Weekers, Greet Van den Berghe
Aug 9, 2003·Critical Care Medicine·Jason ShipmanNaji N Abumrad
Jul 1, 2006·Current Opinion in Critical Care·Benjamin A Kohl, Clifford S Deutschman
Dec 24, 1997·Acta Paediatrica. Supplement·E ArvatE Ghigo
Dec 24, 1997·Acta Paediatrica. Supplement·B B Bercu, R F Walker
Aug 28, 2010·International Journal of Peptides·Johannes D Veldhuis, Cyril Y Bowers
May 19, 1998·Journal of Endocrinological Investigation·L GianottiE Ghigo
Nov 19, 1997·Journal of Endocrinological Investigation·J I MechanickR H Cobin
Jun 15, 2015·The Lancet. Diabetes & Endocrinology·Eric FliersAnita Boelen
Jan 10, 2006·Critical Care Clinics·Dieter Mesotten, Greet Van den Berghe
Nov 28, 2006·Endocrinology and Metabolism Clinics of North America·Dieter Mesotten, Greet Van den Berghe
Apr 19, 2005·European Journal of Internal Medicine·Björn EllgerGreet Van den Berghe
Sep 20, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·Liese Mebis, Greet Van den Berghe
Jan 22, 2002·Best Practice & Research. Clinical Endocrinology & Metabolism·G Van den Berghe
Nov 5, 2004·Current Opinion in Pharmacology·Ilse Vanhorebeek, Greet Van den Berghe
Jun 13, 2003·Endocrinology and Metabolism Clinics of North America·Greet Van den Berghe
Aug 3, 1999·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·G Van den Berghe
Jun 30, 2009·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·David J MarquardtMark W Hall
Jun 8, 2004·Endocrine Reviews·Aart J van der LelyEzio Ghigo
Jan 14, 2000·The Journal of Clinical Endocrinology and Metabolism·G Van den BergheJ D Veldhuis
Nov 27, 2020·Frontiers in Endocrinology·Mohamed Hamdy Elkarow, Amr Hamdy

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