PMID: 2119421Sep 1, 1990Paper

Pituitary-thyroid axis, prolactin and growth hormone in patients with acute stroke

Journal of Internal Medicine
T OlssonE Hägg

Abstract

The pituitary-thyroid axis, serum prolactin and growth hormone levels were studied in 29 patients within 9 d of onset of acute ischaemic stroke. When compared to a control group of 80-year-old volunteers (n = 33), stroke patients were found to have elevated free thyroxine indices (P = 0.008), after adjustment for age and sex. Seventeen (81%) of the stroke patients showed a paradoxical rise in growth hormone in response to thyrotropin releasing hormone (TRH). In a multiple regression model, disorientation was associated with a low thyrotropin response to TRH (P = 0.02 and P = 0.04; 20 and 60 min after TRH, respectively). Disorientation was also positively correlated with the prolactin response to TRH (P = 0.045 after 60 min). Growth hormone levels were predicted by extensive motor impairment (P = 0.02). In conclusion, changes in pituitary and thyroid hormones were commonly observed after stroke and were closely associated with cognitive and/or motor impairment.

References

Jan 1, 1986·Acta Medica Scandinavica·E HäggP O Wester
Jan 1, 1985·Stroke; a Journal of Cerebral Circulation·T StrandP O Wester
Sep 1, 1985·The Medical Clinics of North America·J M Tibaldi, M I Surks

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Citations

Aug 13, 2011·Neurocritical Care·Hagen B HuttnerMartin Köhrmann
Mar 20, 1997·Journal of the Neurological Sciences·A JohanssonM Fagerlund
May 20, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·S SchwarzM Bettendorf
Feb 26, 2000·Journal of Internal Medicine·A JohanssonT Olsson
Jun 1, 1993·Stroke; a Journal of Cerebral Circulation·G M PepperS Deutsch
Apr 22, 2011·The Journal of Clinical Endocrinology and Metabolism·Daniel ÅbergN David Aberg
May 15, 2020·Journal of Clinical Pharmacy and Therapeutics·Yihao ChenJunji Wei

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