PMID: 183444Sep 1, 1976

Pituitary-thyroid interrelationship in rats exposed to different environmental temperatures

Acta Endocrinologica
E TalA Zerachie


The present work intended to show interrelationships between triiodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH) and cyclic adenosine 3'5'-monophosphate (cyclic AMP) in both the pituitary and the thyroid. Experiments were carried out on animals exposed to 0 and 37 degrees C for 4 days and to 34 degrees C for 21 days. Control animals were maintained at 22 degrees C. T4 serum levels of 2.6, 4.0 1.1 and 0.42 mug/100 ml serum, and T3 levels of 95, 135, 65 and 36 ng/100 ml serum were recorded at 22, 0, 34 and 37 degrees C, respectively. The observed serum TSH levels were 265, 192, 237 and 182 mug/100 ml serum in rats exposed to 22, 0, 34 and 37 degrees C, respectively. Pituitary TSH content was similar at 22, 0 and 34 degrees C whereas the content in the 37 degrees C exposed rats was twice that of controls. Thyroid cyclic AMP levels were not significantly different among the various experimental groups. The content of cyclic AMP in the pituitary was higher at 34 degrees C by 125% and 37 degrees C by 240%, and lower at 0 degress C by 56% with regard to the control. These results suggest that the 0 and 34 degrees C exposed rats reach a new steady state in the control of thyroid hormones secretion rate. However, at...Continue Reading


Jan 1, 1979·Pharmacology & Therapeutics. Part B: General & Systematic Pharmacology·K D DöhlerA von zur Mühlen
Jan 1, 1989·Pharmacology & Therapeutics·M J Fregly
Nov 26, 1998·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·N ShvarevaU A Sod-Moriah

Related Concepts

Measurement of Serum Thyroid Stimulating Hormone
Pituitary Diseases
Thyroxine Measurement
Cyclic AMP
Secretory Rate
Process of Secretion
Thyroid Diseases
Cyclic Adenosine Monophosphate Measurement

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.