Pituitary volume in psychosis.

The British Journal of Psychiatry : the Journal of Mental Science
Carmine M ParianteC Pantelis

Abstract

Patients with psychosis have activation of the hypothalamic-pituitary-adrenal (HPA) axis during the acute phase of the psychosis. Whether this has any morphological consequences for the pituitary gland is currently unknown. To examine pituitary volume variation in people at different stages of psychotic disorder. Pituitary volume was measured using 1.5 mm, coronal magnetic resonance images in 24 people with first-episode psychosis, 51 with established schizophrenia and 59 healthy controls. Compared with the control group, the people with first-episode psychosis had pituitary volumes that were 10% larger, whereas those with established schizophrenia had pituitary volumes that were 17% smaller. In both of the groups with psychosis, there was no difference in pituitary volume between those receiving typical antipsychotic drugs and those receiving atypical antipsychotics. The first episode of a psychosis is associated with a larger pituitary volume, which we suggest is due to activation of the HPA axis. The smaller pituitary volume in the group with established schizophrenia could be the consequence of repeated episodes of HPA axis hyperactivity.

References

Feb 11, 1991·The Journal of Clinical Endocrinology and Metabolism·K R KrishnanC B Nemeroff
Aug 1, 1990·The Journal of Clinical Endocrinology and Metabolism·S N LurieK R Krishnan
Jul 1, 1987·Clinical Radiology·K MineuraH Kagaya
Feb 1, 1970·The American Journal of Psychiatry·E J SacharR Mehlman
Jan 1, 1993·The British Journal of Psychiatry : the Journal of Mental Science·P BebbingtonS Lewis
Apr 1, 1993·Radiology·A D Elster
Jan 1, 1996·Schizophrenia Bulletin·P D McGorryH J Jackson
May 2, 2000·The British Journal of Psychiatry : the Journal of Mental Science·S AminG Harrison
Dec 7, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J EritaiaC Pantelis
Mar 29, 2001·Biological Psychiatry·C M Pariante, A H Miller
Aug 28, 2001·Biological Psychiatry·R B SassiJ C Soares
Dec 26, 2001·Archives of General Psychiatry·I Myin-GermeysP A Delespaul
Nov 2, 2002·The British Journal of Psychiatry : the Journal of Mental Science·David Cotter, Carmine M Pariante
Feb 4, 2003·The American Journal of Psychiatry·Martina C M RyanJogin H Thakore
Mar 26, 2003·Psychoneuroendocrinology·U Halbreich, L S Kahn
Jul 2, 2003·Journal of Neuroendocrinology·Carmine M Pariante

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Citations

Apr 26, 2008·European Archives of Psychiatry and Clinical Neuroscience·Tomas HajekMartin Alda
Aug 21, 2008·Psychological Medicine·S E SaarniJ Lönnqvist
Dec 2, 2011·Psychological Medicine·P HabetsM Marcelis
Dec 18, 2013·Development and Psychopathology·Elaine F WalkerJoy L Brasfield
Oct 13, 2006·Molecular Psychiatry·K M R PrasadV L Nimgaonkar
Jun 16, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Carmine M ParianteRobin M Murray
Jun 2, 2010·Schizophrenia Bulletin·Craig MorganRobin M Murray
Apr 21, 2011·Schizophrenia Bulletin·Nitin GogtayChristos Pantelis
Jul 29, 2006·Current Opinion in Psychiatry·Kris Naudts, Sheilagh Hodgins
Aug 17, 2006·The Australian and New Zealand Journal of Psychiatry·Richard Porter
Oct 1, 2006·Acta Neuropsychiatrica·Richard J Porter, Peter Gallagher
Sep 4, 2013·Hormones and Behavior·Hanan D TrotmanElaine F Walker
Dec 2, 2010·The British Journal of Psychiatry : the Journal of Mental Science·Mark Agius
Aug 3, 2007·International Review of Psychiatry·C PantelisP D McGorry
Jul 16, 2005·Stress : the International Journal on the Biology of Stress·Carmine M Pariante
Dec 10, 2008·Stress : the International Journal on the Biology of Stress·Livia A Carvalho, Carmine M Pariante
Feb 5, 2013·Journal of Psychiatric Research·Chiara SpironelliAlessandro Angrilli
Dec 12, 2012·Psychiatry Research·Stefania TogninPaolo Brambilla
May 23, 2012·Psychiatry Research·Tsutomu TakahashiMichio Suzuki
Feb 5, 2011·European Psychiatry : the Journal of the Association of European Psychiatrists·E PerrierS Frangou
Nov 16, 2010·Schizophrenia Research·Jeannine BüschlenAnita Riecher-Rössler
Apr 22, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Patricia A ZunszainCarmine M Pariante
Feb 23, 2010·Psychoneuroendocrinology·David A CousinsAdrian J Lloyd
Dec 23, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Murad AtmacaAlperen Kayali
Dec 15, 2015·Neuroscience and Biobehavioral Reviews·Roberto C MelcangiLuis M Garcia-Segura
Jun 16, 2009·Hormones and Behavior·Roberto Cosimo Melcangi, Luis Miguel Garcia-Segura
Jul 3, 2009·Psychoneuroendocrinology·Jiska S PeperHilleke E Hulshoff Pol
Jul 23, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tsutomu TakahashiChristos Pantelis
Sep 24, 2015·Molecular Psychiatry·M A Landek-SalgadoA Sawa
Feb 26, 2009·Psychiatry Research·Valentina LorenzettiMurat Yücel
Jul 22, 2008·Psychoneuroendocrinology·Valeria MondelliCarmine M Pariante
Oct 16, 2007·Psychiatry Research·Belinda GarnerPatrick D McGorry
Jun 23, 2015·Annals of the New York Academy of Sciences·Renée A Duckworth
Dec 23, 2006·Psychiatry Research·Kalliopi TournikiotiPaolo Brambilla
Jan 16, 2007·Clinical Psychology Review·Inez Myin-Germeys, Jim van Os
Nov 13, 2009·Annals of the New York Academy of Sciences·Andrea H MarquesEsther M Sternberg
Nov 16, 2010·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Amy R ZipurskyNicholas B Allen

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