Pitx2 in Embryonic and Adult Myogenesis

Frontiers in Cell and Developmental Biology
Francisco Hernández-TorresAmelia Eva Aránega

Abstract

Skeletal muscle is a heterogeneous tissue that represents between 30 and 38% of the human body mass and has important functions in the organism, such as maintaining posture, locomotor impulse, or pulmonary ventilation. The genesis of skeletal muscle during embryonic development is a process controlled by an elaborate regulatory network combining the interplay of extrinsic and intrinsic regulatory mechanisms that transform myogenic precursor cells into functional muscle fibers through a finely tuned differentiation program. However, the capacity of generating muscle still remains once these fibers have matured. Adult myogenesis resembles many of the embryonic morphogenetic episodes and depends on the activation of satellite cells that have the potential to differentiate into new muscle fibers. Pitx2 is a member of the bicoid family of homeodomain transcription factors that play an important role in morphogenesis. In the last decade, Pitx2 has emerged as a key element involved in the fine-tuning mechanism that regulates skeletal-muscle development as well as the differentiation and cell fate of satellite cells in adult muscle. Here we present an integrative view of all aspects of embryonic and adult myogenesis in which Pitx2 is i...Continue Reading

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Citations

Nov 2, 2019·Journal of Dental Research·D H Rosero SalazarJ W Von den Hoff
Sep 27, 2018·Nature Communications·Lauren E ByrnesJulie B Sneddon
Jul 14, 2019·Journal of Muscle Research and Cell Motility·Fiona C Wardle
Oct 28, 2019·Journal of Lipid Research·Anil K AgarwalAbhimanyu Garg
Dec 6, 2019·Frontiers in Cell and Developmental Biology·Linjun HongZhenfang Wu
May 5, 2021·Journal of Cellular and Molecular Medicine·Mingming ChenHong Guo
Jul 25, 2021·International Journal of Molecular Sciences·Jieyun BaiJichao Zhao

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Methods Mentioned

BETA
electron microscopy

Software Mentioned

Myog

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