Pityriasis Lichenoides, Atypical Pityriasis Lichenoides, and Related Conditions: A Study of 66 Cases

The American Journal of Surgical Pathology
Tiziana BorraLorenzo Cerroni

Abstract

Pityriasis lichenoides (PLs) is an uncommon skin disease of unknown etiology. In recent years, an atypical form of PL has been described, showing overlapping features with mycosis fungoides (MF) and lymphomatoid papulosis. We studied 66 patients with an initial histopathologic diagnosis of PL (M:F=34:32; median age, 25 y; range, 7 to 85 y). According to clinical and phenotypic features, cases were classified into 4 categories: (1) Conventional PL (characteristic clinical features of PL without phenotypic aberrations) (n=20; M:F=8:12; median age, 37 y; range, 9 to 74 y); (2) Atypical form of PL (characteristic clinical features of PL with phenotypic aberrations) (n=25; M:F=16:9; median age, 21 y; range, 7 to 72 y). Four of these patients subsequently developed MF; (3) Lymphomatoid papulosis (waxing and waning lesions and positivity for CD30) (n=10; M:F=4:6; median age, 41 y; range, 16 to 83 y); (4) MF (clinical features typical of MF) (n=11; M:F=6:5; median age, 17 y; range, 8 to 85 y). Molecular analyses of clonality of the infiltrate did not reveal relevant differences among these 4 groups. Our study suggests that patients with an initial histopathologic diagnosis of PL may belong to different groups, showing that clinicopatho...Continue Reading

References

Sep 1, 1990·Journal of the American Academy of Dermatology·C GelmettiR Caputo
Sep 1, 1996·Journal of the American Academy of Dermatology·A PanhansY de Prost
Feb 21, 1998·The British Journal of Dermatology·U M NiemczykR Kaufmann
Aug 8, 2002·Archives of Dermatology·Jeffrey M WeinbergStuart R Lessin
Aug 31, 2002·Human Pathology·Cynthia MagroFrank Burns
Sep 10, 2002·Dermatology : International Journal for Clinical and Investigative Dermatology·Dario TomasiniHeinz Kutzner
Mar 29, 2005·Journal of the American Academy of Dermatology·Kazuo KodamaLorenzo Cerroni
Aug 3, 2005·Pediatric Dermatology·Mark D HerronSheryll L Vanderhooft
Oct 3, 2006·Journal of the American Academy of Dermatology·Sacharitha Bowers, Erin M Warshaw
Nov 14, 2006·Journal of the American Academy of Dermatology·Sibel Ersoy-EvansAmy S Paller
Jan 24, 2007·Human Pathology·Cynthia M MagroJingwei Li
Mar 30, 2011·Pediatric Blood & Cancer·Olivia BoccaraSylvie Fraitag
Sep 8, 2011·Pediatric Blood & Cancer·Alessandro PileriAnnalisa Patrizi
Jan 10, 2018·Pediatric Dermatology·Julie B ZangBernard A Cohen

❮ Previous
Next ❯

Citations

Dec 28, 2019·The American Journal of Dermatopathology·Sébastien MenzingerSylvie Fraitag
Jul 25, 2020·Pediatric Dermatology·José Miguel NevesMaria João Paiva Lopes
May 3, 2021·International Journal of Dermatology·Margaret E LangJulio C Sartori-Valinotti
Jun 26, 2021·Clinical and Experimental Dermatology·J LupuS Ingen-Housz-Oro
Oct 7, 2021·Journal of Cutaneous Pathology·Shyam S RaghavanKerri E Rieger

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
PCR
biopsies

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.