Pivotal Advance: eosinophil infiltration of solid tumors is an early and persistent inflammatory host response.

Journal of Leukocyte Biology
Stephania A CormierNancy A Lee

Abstract

Tumor-associated eosinophilia has been observed in numerous human cancers and several tumor models in animals; however, the details surrounding this eosinophilia remain largely undefined and anecdotal. We used a B16-F10 melanoma cell injection model to demonstrate that eosinophil infiltration of tumors occurred from the earliest palpable stages with significant accumulations only in the necrotic and capsule regions. Furthermore, the presence of diffuse extracellular matrix staining for eosinophil major basic protein was restricted to the necrotic areas of tumors, indicating that eosinophil degranulation was limited to this region. Antibody-mediated depletion of CD4+ T cells and adoptive transfer of eosinophils suggested, respectively, that the accumulation of eosinophils is not associated with T helper cell type 2-dependent immune responses and that recruitment is a dynamic, ongoing process, occurring throughout tumor growth. Ex vivo migration studies have identified what appears to be a novel chemotactic factor(s) released by stressed/dying melanoma cells, suggesting that the accumulation of eosinophils in tumors occurs, in part, through a unique mechanism dependent on a signal(s) released from areas of necrosis. Collectively,...Continue Reading

References

Jan 1, 1978·The Journal of Pathology·L M Franks, V J Hemmings
Jan 1, 1992·Clinical Oncology : a Journal of the Royal College of Radiologists·B I DalalK Malakar
Apr 15, 1988·International Journal of Cancer. Journal International Du Cancer·G Schackert, I J Fidler
Feb 25, 1967·Nature·G HudsonJ M Yoffey
Jan 1, 1983·Cancer Metastasis Reviews·R K Oldham
Dec 1, 1981·Journal of Clinical Pathology·D LoweM S Hutt
Jun 1, 1994·American Journal of Respiratory Cell and Molecular Biology·S H GavettM Wills-Karp
Feb 1, 1994·Human Gene Therapy·R I Tepper, J J Mulé
Apr 1, 1993·European Journal of Immunology·S Krüger-KrasagakesT Blankenstein
Mar 1, 2000·Oral Oncology·D T WongP F Weller
Jul 25, 2000·Molecular Medicine Today·C C ParkM H Barcellos-Hoff
Aug 5, 2000·International Journal of Cancer. Journal International Du Cancer·F LozuponeS Fais
Sep 9, 2000·Leukemia Research·R B Herberman
Mar 7, 2001·Lancet·F Balkwill, A Mantovani
Apr 27, 2001·Seminars in Cancer Biology·T D Tlsty
Mar 20, 2002·Nature Reviews. Cancer·M J Bissell, D Radisky
Nov 22, 2002·American Journal of Respiratory Cell and Molecular Biology·Stephania A CormierJames J Lee
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Mar 5, 2003·Annual Review of Immunology·Drew Pardoll
Mar 13, 2003·Immunology and Cell Biology·Christopher R Parish
Jan 28, 2004·The Journal of Cell Biology·Roberta PalumboMarco E Bianchi
Feb 26, 2004·Allergy·A Munitz, F Levi-Schaffer
Mar 17, 2004·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M WislezJ Cadranel
Apr 22, 2004·The Journal of Allergy and Clinical Immunology·Vladislav TemkinFrancesca Levi-Schaffer
Jun 16, 2004·Cancer Immunology, Immunotherapy : CII·Murrium AhmadSelman A Ali
Jul 24, 2004·Immunology·Anna-Lena Stenfeldt, Christine Wennerås
Jul 28, 2004·The American Journal of Pathology·Michael SamoszukOrhan Nalcioglu
Aug 17, 2004·Immunity·Gavin P DunnRobert D Schreiber
Nov 9, 2004·Advances in Cancer Research·Li Yang, David P Carbone
Jun 21, 2005·Springer Seminars in Immunopathology·Adrian F Ochsenbein
Aug 27, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J J Lee, N A Lee

❮ Previous
Next ❯

Citations

Jul 28, 2007·Cancer Immunology, Immunotherapy : CII·Sophia N KaragiannisHannah J Gould
Jun 19, 2012·Cancer Immunology, Immunotherapy : CII·Solène GataultMonique Capron
Nov 3, 2010·Cell and Tissue Research·Revital ShamriLisa A Spencer
Aug 10, 2012·Current Allergy and Asthma Reports·Zhaleh J Amini-VaughanDavid P Huston
Jul 18, 2008·Nature Reviews. Cancer·Craig MurdochClaire E Lewis
Jan 22, 2013·Nature Reviews. Drug Discovery·Patricia C Fulkerson, Marc E Rothenberg
Nov 10, 2007·Cell Death and Differentiation·E UllrichL Zitvogel
Jan 6, 2010·Journal of Oncology·C P Martinelli-KläyT Lombardi
May 22, 2010·Journal of Oncology·Michael C Schmid, Judith A Varner
Nov 13, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lisa G JohnsonMargaret M Madeleine
Jul 12, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Anna E PrizmentAaron R Folsom
Jul 3, 2010·American Journal of Respiratory and Critical Care Medicine·Georgios T StathopoulosTimothy S Blackwell
Apr 16, 2011·American Journal of Respiratory Cell and Molecular Biology·Erik J StemmyStephanie L Constant
Aug 28, 2010·Respiratory Research·Konstantinos DorisGeorgios T Stathopoulos
Dec 18, 2010·Lipids in Health and Disease·Giovani M FaveroSergio P Bydlowski
Jan 19, 2012·Journal of Neuroinflammation·Colleen S Curran, Paul J Bertics
Apr 24, 2008·Molecular Medicine·John R KluneAllan Tsung
Jun 20, 2014·World Journal of Gastroenterology : WJG·Suman Mewa KinooPratistadevi Kanaye Ramdial
Nov 7, 2014·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Jian-Qiang LuVivek Mehta
Aug 17, 2014·Current Opinion in Pharmacology·Nadine Anna Caterina Landolina, Francesca Levi-Schaffer
Oct 19, 2011·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Elisa Lopes e LagesAgnaldo Lopes Silva-Filho
May 20, 2009·Prostaglandins & Other Lipid Mediators·Gail E GrantWilliam S Powell
Feb 24, 2009·Biochimica Et Biophysica Acta·Steven MaltbyKelly M McNagny
May 8, 2007·The Journal of Allergy and Clinical Immunology·Elizabeth A JacobsenJames J Lee
May 1, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Michael T LotzeAnna Rubartelli
Aug 2, 2008·Allergy·E Jensen-JarolimH Gould
Jul 2, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Michele C PereiraLuiz P Kowalski
Mar 30, 2012·Ultrastructural Pathology·Rosario Alberto CarusoLuciana Rigoli
Apr 19, 2015·Journal of Medical Case Reports·Yoshikazu KobayashiHideki Mizutani
Jan 16, 2014·MAbs·Debra H JosephsSophia N Karagiannis
Mar 24, 2015·Molecular and Clinical Oncology·Priscila Oliveira DE LimaMichele Conceição Pereira
Sep 24, 2013·Progress in Lipid Research·William S Powell, Joshua Rokach
May 11, 2010·Journal of Theoretical Biology·Raluca EftimieDavid J D Earn
Nov 30, 2010·Archives of Oral Biology·Michele Conceição PereiraLuiz Paulo Kowalski
Jan 15, 2015·Immunology and Cell Biology·Frann Antignano, Colby Zaph
Sep 13, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Lars HarbaumCord Langner
Nov 12, 2014·Frontiers in Immunology·Lisa A SpencerPeter F Weller
May 2, 2014·Frontiers in Oncology·Christian StockmannIris Helfrich
Feb 27, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Anna E PrizmentPaul J Limburg

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