Pivotal involvement of neurogenic mechanism in subcutaneous bee venom-induced inflammation and allodynia in unanesthetized conscious rats

Experimental Neurology
Huisheng ChenLars Arendt-Nielsen

Abstract

The bee venom (BV) model is a valid inflammatory pain model in animals and has been extended to human studies using its principle protein, mellitin. After subcutaneous (s.c.) injection of BV, long-lasting spontaneous nociception followed by thermal hyperalgesia, static allodynia, and local inflammatory response (edema) can be observed in rats. We hypothesize that (1) neurogenic components may contribute to the BV-induced inflammatory response and (2) static and dynamic mechanical allodynia may exist simultaneously in the BV model. Using different approaches including sciatic nerve transection (SCT), L4-L6 dorsal rhizotomy (DRT) and local treatment of the sciatic nerve with capsaicin, we found that SCT, DRT, and local capsaicin onto the sciatic nerve produced a significant inhibition of the BV-induced increase in volume of the injected paw, with a stronger effect of the SCT and the local capsaicin treatments than that of the DRT treatment. Static and dynamic mechanical allodynia in the BV test was assessed by measuring the paw withdrawal mechanical threshold and the paw withdrawal latency before and after the BV injection, respectively. Local capsaicin onto the sciatic nerve produced a significant inhibition of the BV-induced de...Continue Reading

References

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Nov 29, 2005·European Journal of Pain : EJP·Hiroyuki SumikuraLars Arendt-Nielsen

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Citations

Mar 3, 2015·Toxicon : Official Journal of the International Society on Toxinology·Simone C YamasakiPaulo F Silveira
Aug 5, 2014·Biological & Pharmaceutical Bulletin·Seung-Heon ShinKwan-Kyu Park
Jun 19, 2010·Progress in Neurobiology·Jun Chen, William R Lariviere
Oct 27, 2009·The Journal of Pain : Official Journal of the American Pain Society·Hui-Sheng ChenSu-Jie Lu
Apr 12, 2013·Stress : the International Journal on the Biology of Stress·Hui-Sheng ChenQing Lin
Feb 22, 2011·Toxicon : Official Journal of the International Society on Toxinology·Leonardo A MerloMárcio M Coelho
Apr 4, 2009·Physiological Reviews·Jürgen Sandkühler
Nov 22, 2017·PLoS Neglected Tropical Diseases·Luciana Lyra Casais-E-Silva, Catarina Teixeira
May 2, 2018·Toxicon : Official Journal of the International Society on Toxinology·José Roberto Aparecido Dos Santos-PintoMario Sergio Palma

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