Pivotal roles of ILCs in hepatic diseases

International Reviews of Immunology
Shuang YangBing Ni

Abstract

Innate lymphoid cells (ILCs) are involved in the development of mucosal-associated lymphoid tissues and serve as a rapid and early source of the effector cytokines that are typically associated with the T helper cell subsets in response to pathogen-induced changes in the microenvironment. Recent research has implicated ILCs as potential contributing factors to the spectrum of inflammation-related hepatic diseases, particularly hepatitis, fibrosis and carcinoma. In this review, we summarize the current knowledge on the roles of ILCs in these hepatic pathogeneses, providing insights into the underlying cellular and signaling mechanisms to help guide the future research to elucidate the ILCs' characters under normal and diseased conditions and provide interventional targets with therapeutic potential.

References

Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hiromasa HamadaHiromichi Ishikawa
Jun 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephen D HurstRobert L Coffman
Feb 26, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bernd SchnablDavid Brenner
May 4, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Svetlana RadaevaBin Gao
Feb 4, 2005·The Journal of Clinical Investigation·Ramón Bataller, David A Brenner
Mar 18, 2005·Annual Review of Immunology·Louise J McHeyzer-Williams, Michael G McHeyzer-Williams
Mar 29, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jelena S BezbradicaSebastian Joyce
Sep 13, 2005·Biochemical and Biophysical Research Communications·Y Fujii-Kuriyama, J Mimura
Mar 14, 2007·The Journal of Experimental Medicine·Claire DunnMala K Maini
Mar 30, 2007·Nature·Fumiaki OhtakeShigeaki Kato
May 8, 2007·Cell·Tim Hunt, Paolo Sassone-Corsi
May 13, 2008·Gastroenterology·Scott L Friedman
Jun 20, 2008·Nature·Estelle BettelliVijay K Kuchroo
Aug 30, 2008·Cell·Valery KrizhanovskyScott W Lowe
Nov 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takako NagataJay K Kolls
Dec 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Marie-Laure MichelMaria C Leite-de-Moraes
Dec 31, 2008·The Journal of Experimental Medicine·Hiroaki TakatoriJohn J O'Shea
Jun 11, 2009·Journal of Cellular and Molecular Medicine·Pierrick MarvieMichel Samson
Aug 18, 2009·Journal of Autoimmunity·Jeff J SubleskiJonathan M Weiss
Feb 4, 2010·Seminars in Immunopathology·Kerstin WolkRobert Sabat
Jul 29, 2010·Seminars in Liver Disease·Hermann E WasmuthChristian Trautwein
Oct 26, 2010·Blood·Ram SavanHoward A Young
Nov 3, 2010·Advances in Immunology·Daniel Mucida, Hilde Cheroutre
Jan 5, 2011·Immunity·Gregory F SonnenbergDavid Artis
Jan 14, 2011·Annual Review of Medicine·Kazuhiko Bessho, Jorge A Bezerra
Jan 22, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zheng ZhangFu-Sheng Wang
Apr 6, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ogyi ParkBin Gao
Apr 12, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Won-Il JeongBin Gao
Apr 14, 2011·Journal of Leukocyte Biology·Jeremy P McAleer, Jay K Kolls

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Citations

Mar 8, 2016·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·D YangB Ni
Jun 24, 2017·Pharmacology & Therapeutics·Ming-Jiang XuBin Gao
Jan 8, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Elena Gómez-MassaEstela Paz-Artal
Aug 23, 2018·World Journal of Gastroenterology : WJG·Qi ZhangTing-Bo Liang
Jul 1, 2021·European Journal of Immunology·Xiaodong YuanCheng Sun

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