Piwi-interacting RNAs in cancer: emerging functions and clinical utility

Molecular Cancer
Kevin W NgVictor D Martinez

Abstract

PIWI-interacting RNAs (piRNAs) are emerging players in cancer genomics. Originally described in the germline, there are over 20,000 piRNA genes in the human genome. In contrast to microRNAs, piRNAs interact with PIWI proteins, another member of the Argonaute family, and function primarily in the nucleus. There, they are involved in the epigenetic silencing of transposable elements in addition to the transcriptional regulation of genes. It has recently been demonstrated that piRNAs are also expressed across a variety of human somatic tissue types in a tissue-specific manner. An increasing number of studies have shown that aberrant piRNA expression is a signature feature across multiple tumour types; however, their specific tumorigenic functions remain unclear. In this article, we discuss the emerging functional roles of piRNAs in a variety of cancers, and highlight their potential clinical utilities.

References

Jun 6, 2002·Trends in Genetics : TIG·E Gerhart H Wagner, Klas Flärdh
Aug 16, 2003·Developmental Cell·Alexei A AravinThomas Tuschl
Mar 16, 2004·Science·Haig H Kazazian
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stefano VoliniaCarlo M Croce
Jun 6, 2006·Nature·Angélique GirardMichelle A Carmell
Jul 1, 2006·Science·Vasily V VaginPhillip D Zamore
Mar 31, 2007·Developmental Cell·Michelle A CarmellGregory J Hannon
Apr 21, 2007·Science·Alexei A AravinGregory J Hannon
Mar 14, 2008·The New England Journal of Medicine·Manel Esteller
Mar 29, 2008·Science·Paulo P AmaralJohn S Mattick
Jan 17, 2009·Nature Reviews. Genetics·Megha Ghildiyal, Phillip D Zamore
Feb 4, 2009·Nature Reviews. Genetics·Tim R MercerJohn S Mattick
Sep 19, 2009·Nature Reviews. Genetics·Richard Cordaux, Mark A Batzer
Nov 3, 2009·The Journal of Pathology·Ryan J TaftJohn S Mattick
Mar 24, 2010·Seminars in Cancer Biology·Miriam K Konkel, Mark A Batzer
May 21, 2010·Journal of Cell Science·Josien C van Wolfswinkel, René F Ketting
Sep 3, 2010·Genes & Development·Eric M Phizicky, Anita K Hopper
Jan 5, 2011·Proceedings of the National Academy of Sciences of the United States of America·Yuan TianDinshaw J Patel
Mar 24, 2011·Nature Reviews. Molecular Cell Biology·Mikiko C SiomiAlexei A Aravin
Apr 15, 2011·Molecular Cancer·Ewan A GibbWan L Lam
May 17, 2011·Cardiovascular Drugs and Therapy·Christopher L Holley, Veli K Topkara
May 28, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jia ChengQing-Ning Li
Jun 28, 2011·Trends in Molecular Medicine·Stefania BortoluzziAndrea Bisognin
Sep 20, 2011·Journal of Cellular Biochemistry·Sara Siddiqi, Igor Matushansky
Oct 13, 2011·PloS One·Ewan A GibbWan L Lam
Nov 19, 2011·Nature Reviews. Genetics·Manel Esteller
Jun 30, 2012·Science·Eunjung LeeUNKNOWN Cancer Genome Atlas Research Network
Sep 8, 2012·Nature·UNKNOWN ENCODE Project Consortium
Oct 3, 2012·International Journal of Oncology·Alessandro AllegraCaterina Musolino
Oct 23, 2012·Frontiers in Genetics·Ryusuke SuzukiYohei Kirino
Dec 12, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·G HuangX Zhang
Feb 9, 2013·Genes & Development·Adrien Le ThomasKatalin Fejes Tóth
Feb 26, 2013·Developmental Cell·Xiao A HuangHaifan Lin
Mar 8, 2013·Current Opinion in Cell Biology·Jamy C Peng, Haifan Lin
May 10, 2013·Annual Review of Biophysics·Ross C Wilson, Jennifer A Doudna
Sep 3, 2013·Surgical Oncology·Hao ZhangCaigang Liu
Oct 2, 2013·Annual Review of Pathology·Gianpiero Di LevaCarlo M Croce
Nov 1, 2013·Nature Reviews. Drug Discovery·Hui LingGeorge A Calin
Nov 28, 2013·Nucleic Acids Research·Ana Kozomara, Sam Griffiths-Jones

❮ Previous
Next ❯

Citations

Oct 8, 2016·Transcription·Didier Auboeuf
Dec 3, 2016·Nucleic Acids Research·I-Fang ChungWei-Chung Cheng
Nov 25, 2016·Scientific Reports·Malin NientiedtJörg Ellinger
Dec 6, 2017·Genes·Jing WangYan Guo
Oct 25, 2017·Scientific Data·Erin A MarshallWan L Lam
Oct 19, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ling ZhangXiaodong Han
Jan 4, 2018·BMC Bioinformatics·Chun-Chi ChenByung-Jun Yoon
Feb 8, 2018·Clinical Epigenetics·Frauke G HeinemannJörg Ellinger
Jul 4, 2019·Database : the Journal of Biological Databases and Curation·Azhar MuhammadXiaoyuan Song
Dec 21, 2018·Journal of Applied Physiology·Glenn D WadleyBianca C Bernardo
Sep 13, 2019·Wiley Interdisciplinary Reviews. RNA·Prakash KharelSoumitra Basu
Jan 11, 2018·Scientific Reports·Victor D MartinezKevin L Bennewith
Nov 27, 2019·Veterinary and Comparative Oncology·Md Mahfuzur RahmanNaoki Miura
Oct 16, 2019·Molecular Genetics and Genomics : MGG·Jyoti RoyBibekanand Mallick
Sep 13, 2017·Molecular Genetics and Genomics : MGG·Heeyoun Bunch
Jan 18, 2020·International Journal of Molecular Sciences·Lin ChenXiaofeng Zhou
Jul 3, 2018·Oncotarget·Ezequiel LacunzaMagalí Pellon-Maison
Oct 23, 2016·Oncotarget·Preethi KrishnanSambasivarao Damaraju
Nov 16, 2019·Aging·Ye ChengWeihong Shi
May 23, 2017·Oncology Letters·Monika LitwinWojciech Witkiewicz
Jan 31, 2018·Genetics·Ryan J GleasonXin Chen
May 15, 2018·The Journal of Pathology·Vassilis G GorgoulisIoannis P Trougakos
Nov 2, 2018·Viruses·Marie-Laure PlissonnierMirjam B Zeisel
Nov 30, 2018·World Journal of Urology·Chenming ZhaoJörg Ellinger
Aug 11, 2019·Molecular Cancer·Yongmei LiuWenhua Xu
Dec 10, 2019·Cellular and Molecular Life Sciences : CMLS·Alexios-Fotios A MentisAthanasios G Papavassiliou
Apr 18, 2017·Journal of Experimental & Clinical Cancer Research : CR·Zhiliang LuJie He
May 1, 2018·Biological Research for Nursing·Komal P SinghKord M Kober
Jan 9, 2018·Expert Review of Molecular Diagnostics·Ivan A ZaporozhchenkoPavel P Laktionov
Mar 14, 2020·Archives of Dermatological Research·Johannes PammerMichael Mildner

❮ Previous
Next ❯

Methods Mentioned

BETA
RNAseq
biopsies
xenograft
PCR

Software Mentioned

EndNote

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Related Papers

Molecular Cell
Anita G SetoNelson C Lau
Frontiers in Genetics
Ryusuke SuzukiYohei Kirino
Bioorganicheskaia khimiia
Yong HuangHong Tao Ren
Clinica Chimica Acta; International Journal of Clinical Chemistry
Jia ChengQing-Ning Li
© 2022 Meta ULC. All rights reserved