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PIWI-interacting RNAs: small RNAs with big functions

Nature Reviews. Genetics

Nov 18, 2018

Deniz M OzataPhillip D Zamore

Abstract

In animals, PIWI-interacting RNAs (piRNAs) of 21-35 nucleotides in length silence transposable elements, regulate gene expression and fight viral infection. piRNAs guide PIWI proteins to cleave target RNA, promote heterochromatin assembly and methylate DNA. The architecture of the piRNA...read more

Mentioned in this Paper

Biochemical Pathway
PIWIL1 gene
PIWI Subfamily of Argonaute Proteins
Virus
Virus Diseases
Heterochromatin Assembly
Genes
Methylate
Gene Expression
Heterochromatin
105
2
317
1
Paper Details
References
  • References6
  • Citations12
12

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PIWI-interacting RNAs: small RNAs with big functions

Nature Reviews. Genetics

Nov 18, 2018

Deniz M OzataPhillip D Zamore

PMID: 30446728

DOI: 10.1038/s41576-018-0073-3

Abstract

In animals, PIWI-interacting RNAs (piRNAs) of 21-35 nucleotides in length silence transposable elements, regulate gene expression and fight viral infection. piRNAs guide PIWI proteins to cleave target RNA, promote heterochromatin assembly and methylate DNA. The architecture of the piRNA...read more

Mentioned in this Paper

Biochemical Pathway
PIWIL1 gene
PIWI Subfamily of Argonaute Proteins
Virus
Virus Diseases
Heterochromatin Assembly
Genes
Methylate
Gene Expression
Heterochromatin
105
2
317
1

Similar Papers Found In These Feeds

Parasite evolution

Parasite evolution involves the heritable genetic changes that a parasite accumulates during its life time. Discover the latest research on parasite evolution here.

Transposable Elements

Transposable elements (tes) have profound effects on the structure, function and evolution of their host genomes.

Related Papers

Molecular Cell

Posttranscriptional regulation of gene expression by Piwi proteins and piRNAs

Molecular CellOctober 4, 2014
Toshiaki Watanabe, Haifan Lin
Zhonghua nan ke xue = National journal of andrology

Biogenesis and functions of piRNAs in the reproductive system of male mice

Zhonghua nan ke xue = National journal of andrologyAugust 20, 2016
Ling Zhang, xiao-dong Han
Paper Details
References
  • References6
  • Citations12
12
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