Pixel distribution analysis: can it be used to distinguish clear cell carcinomas from angiomyolipomas with minimal fat?

Radiology
Onofrio A CatalanoPeter F Hahn

Abstract

To retrospectively determine if pixel histogram analysis of unenhanced computed tomographic (CT) images can be used to distinguish angiomyolipomas (AMLs) with minimal fat from clear cell renal cell carcinomas (CCRCCs). The human studies committee approved this HIPAA-complaint study, with waiver of informed consent. Patients with pathologically proved AMLs lacking visible macroscopic fat at CT and patients with pathologically proved CCRCCs were included. Lesions were measured, and a histogram (number of pixels with each attenuation) was calculated electronically within a central region of interest. The percentage of pixels below the attenuation thresholds -20 HU and 10 HU was calculated in both cohorts. The unpaired Student t test was used to compare the average percentage of subthreshold pixels at each threshold. P < .05 indicated a significant difference. The number of lesions with more than the selected percentage of subthreshold pixels was calculated in both groups, and the chi(2) test was used to test the significance of differences between cohorts. The area under the receiver operating characteristic (ROC) curve was used to determine if any percentage of subthreshold pixels could be used to differentiate between the two co...Continue Reading

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Citations

Jun 19, 2009·Abdominal Imaging·Ghazi AlshumraniTony Panzarella
Jan 22, 2009·AJR. American Journal of Roentgenology·Claus SimpfendorferErick M Remer
Jan 24, 2012·AJR. American Journal of Roentgenology·Humaira S ChaudhryAmy M Neville
Oct 24, 2013·AJR. American Journal of Roentgenology·Ching-Wei YangKuang-Kuo Chen
Jul 26, 2013·AJR. American Journal of Roentgenology·Humaira S ChaudhryAmy M Neville
May 26, 2012·Urology Annals·Pankaj Kumar GargVibhav Vibhav
May 23, 2014·AJR. American Journal of Roentgenology·Stella K KangHersh Chandarana
Jan 23, 2016·AJR. American Journal of Roentgenology·Chae Jin JeongChan Kyo Kim
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Aug 19, 2015·World Journal of Surgical Oncology·Yuki KobariKazunari Tanabe
Jan 20, 2015·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Sungmin Woo, Jeong Yeon Cho
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Feb 12, 2019·Kidney Cancer·Tim J van OostenbruggePeter F A Mulders
Mar 9, 2021·Radiology Case Reports·Koji TakumiTakashi Yoshiura

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