Pixel super-resolution using wavelength scanning

Light, Science & Applications
Wei LuoAydogan Ozcan

Abstract

Undersampling and pixelation affect a number of imaging systems, limiting the resolution of the acquired images, which becomes particularly significant for wide-field microscopy applications. Various super-resolution techniques have been implemented to mitigate this resolution loss by utilizing sub-pixel displacements in the imaging system, achieved, for example, by shifting the illumination source, the sensor array and/or the sample, followed by digital synthesis of a smaller effective pixel by merging these sub-pixel-shifted low-resolution images. Herein, we introduce a new pixel super-resolution method that is based on wavelength scanning and demonstrate that as an alternative to physical shifting/displacements, wavelength diversity can be used to boost the resolution of a wide-field imaging system and significantly increase its space-bandwidth product. We confirmed the effectiveness of this new technique by improving the resolution of lens-free as well as lens-based microscopy systems and developed an iterative algorithm to generate high-resolution reconstructions of a specimen using undersampled diffraction patterns recorded at a few wavelengths covering a narrow spectrum (10-30 nm). When combined with a synthetic-aperture...Continue Reading

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Citations

Mar 7, 2019·Light, Science & Applications·Yair RivensonAydogan Ozcan
Jul 17, 2019·Journal of Biophotonics·Tairan LiuAydogan Ozcan
Oct 28, 2019·Light, Science & Applications·Yibo ZhangAydogan Ozcan
Aug 23, 2018·Optics Express·You ZhouQionghai Dai
Nov 9, 2017·Scientific Reports·Anwar HussainXu Liu
Nov 2, 2019·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Daniel DahanZeev Zalevsky
Jun 6, 2020·Biomedical Optics Express·Ramona CormanHamed Merdji
Dec 14, 2016·Scientific Reports·Farnoud Kazemzadeh, Alexander Wong
Jun 15, 2017·Journal of Biomedical Optics·You ZhouQionghai Dai
Apr 14, 2018·Optics Letters·Manon RostykusChristophe Moser
Nov 25, 2018·Optics Express·Yinxu BianAydogan Ozcan
Mar 17, 2019·Optics Express·X F ZhangY D Zheng
Dec 28, 2019·Optics Express·Cheng GuoZhengjun Liu
Mar 4, 2020·Optics Express·Wenhui XuFucai Zhang
Mar 12, 2016·Scientific Reports·Wei LuoAydogan Ozcan
Nov 13, 2017·Journal of Biomedical Optics·Anwar HussainXu Liu
Mar 10, 2019·Scientific Reports·Tairan LiuAydogan Ozcan
Apr 1, 2019·The Review of Scientific Instruments·Zihan WangXianyue Kong
Dec 3, 2016·Scientific Reports·Yair RivensonAydogan Ozcan
Nov 22, 2018·Applied Optics·Qichang AnHaifeng Cao
Jan 8, 2021·Biomedical Optics Express·Youqiang ZhuLi Xuan
Sep 3, 2017·Methods : a Companion to Methods in Enzymology·Yichen Wu, Aydogan Ozcan

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Methods Mentioned

BETA
chip
chips
imaging techniques

Software Mentioned

MATLAB
LabVIEW

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