PKA increases in the olfactory bulb act as unconditioned stimuli and provide evidence for parallel memory systems: pairing odor with increased PKA creates intermediate- and long-term, but not short-term, memories

Learning & Memory
Matthew T GrimesJohn H McLean

Abstract

Neonatal odor-preference memory in rat pups is a well-defined associative mammalian memory model dependent on cAMP. Previous work from this laboratory demonstrates three phases of neonatal odor-preference memory: short-term (translation-independent), intermediate-term (translation-dependent), and long-term (transcription- and translation-dependent). Here, we use neonatal odor-preference learning to explore the role of olfactory bulb PKA in these three phases of mammalian memory. PKA activity increased normally in learning animals 10 min after a single training trial. Inhibition of PKA by Rp-cAMPs blocked intermediate-term and long-term memory, with no effect on short-term memory. PKA inhibition also prevented learning-associated CREB phosphorylation, a transcription factor implicated in long-term memory. When long-term memory was rescued through increased β-adrenoceptor activation, CREB phosphorylation was restored. Intermediate-term and long-term, but not short-term odor-preference memories were generated by pairing odor with direct PKA activation using intrabulbar Sp-cAMPs, which bypasses β-adrenoceptor activation. Higher levels of Sp-cAMPs enhanced memory by extending normal 24-h retention to 48-72 h. These results suggest t...Continue Reading

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Citations

Jul 30, 2014·Frontiers in Behavioral Neuroscience·Michelle T TongThomas A Cleland
Jan 13, 2018·Frontiers in Cellular Neuroscience·Abhinaba GhoshQi Yuan
Apr 29, 2016·Journal of Neurophysiology·Shirin ModarresiQi Yuan
Apr 17, 2020·Learning & Memory·Michaelina N NarteyJohn H McLean
Jan 17, 2015·Learning & Memory·Matthew T GrimesJohn H McLean

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