PKC-alpha mediated alterations of indoleamine contents in diabetic rat brain

Brain Research Bulletin
R RamakrishnanN Suthanthirarajan

Abstract

We previously have reported that acute or chronic diabetes in animals resulted in altered neurotransmitter levels. In this study, we investigated the concentrations of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in discrete areas of brain viz. striatum (ST), hippocampus (HC), hypothalamus (HT), midbrain (MB), pons medulla (PM), cerebellum (CB) and cerebral cortex (CCX) of control, untreated diabetic and insulin treated diabetic rats after 30 days. Alloxan (45 mg/kg) diabetic untreated rats, which showed hyperglycemia (>250 mg%), revealed significant increases of 5-HT level in ST, MB, PM, CB and CCX and the 5-HIAA level found to be increased significantly in ST, HC and MB. Whereas the insulin treated rats, which was maintained under normal glucose level (80-110 mg%), showed no significant changes in any of the areas studied. The expressions of PKC-alpha studied by immunoblotting also showed significant changes in ST, HC, MB, PM, CB and CCX that is identical to the changes of both 5-HT and 5-HIAA under similar condition, suggesting that the PKC-alpha may regulate the synthesis and release of indoleamines in diabetic animals.

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Citations

Apr 26, 2008·Endocrine Reviews·Christopher T Kodl, Elizabeth R Seaquist
Jan 5, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Xiaohan XuGuoqing Tian
Jun 13, 2009·Diabetes Research and Clinical Practice·Naomune YamamotoKuniaki Otsuka
Mar 14, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Angela PassaroGiovanni Zuliani
Jan 13, 2009·Biochimica Et Biophysica Acta·Jarbas S Roriz-FilhoMatheus Roriz-Cruz
Dec 2, 2009·The Journal of Primary Prevention·Kathryn A Brookmeyer, Christopher C Henrich
Sep 5, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Jason D HuberKimberly A Houser
Jul 22, 2019·Brain Research Bulletin·R Ramakrishnan

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