PKC in Regenerative Therapy: New Insights for Old Targets

Pharmaceuticals
Marta RuiSimona Collina

Abstract

Effective therapies for chronic or non-healing wounds are still lacking. These tissue insults often result in severe clinical complications (i.e., infections and/or amputation) and sometimes lead to patient death. Accordingly, several research groups have focused their efforts in finding innovative and powerful therapeutic strategies to overcome these issues. On the basis of these considerations, the comprehension of the molecular cascades behind these pathological conditions could allow the identification of molecules against chronic wounds. In this context, the regulation of the Protein Kinase C (PKC) cascade has gained relevance in the prevention and/or reparation of tissue damages. This class of phosphorylating enzymes has already been considered for different physiological and pathological pathways and modulation of such enzymes may be useful in reparative processes. Herein, the recent developments in this field will be disclosed, highlighting the pivotal role of PKC α and δ in regenerative medicine. Moreover, an overview of well-established PKC ligands, acting via the modulation of these isoenzymes, will be deeply investigated. This study is aimed at re-evaluating widely known PKC modulators, currently utilized for treati...Continue Reading

References

Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·I V YannasG F Murphy
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·H FujikiR E Moore
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P E Driedger, P M Blumberg
Dec 1, 1995·The Journal of Biological Chemistry·A C Newton
Sep 1, 1993·The Biochemical Journal·S E WilkinsonJ S Nixon
Apr 1, 1997·Progress in Neuro-psychopharmacology & Biological Psychiatry·E A Van der ZeeJ F Disterhoft
Feb 24, 2001·Bioorganic & Medicinal Chemistry Letters·D MaP M Blumberg
Aug 4, 2001·The American Journal of Pathology·G F Pierce
Nov 20, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·F Battaini
Mar 21, 2002·Nature Reviews. Cancer·Michael M GottesmanSusan E Bates
Aug 23, 2002·Pharmacology & Therapeutics·Keykavous Parang, Philip A Cole
Jun 18, 2003·Accounts of Chemical Research·Victor E Marquez, Peter M Blumberg
Jun 19, 2003·The Journal of Biological Chemistry·Trond LamarkTerje Johansen
Jan 23, 2004·Cancer Investigation·Jeremy Kortmansky, Gary K Schwartz
Mar 18, 2004·Journal of the American Chemical Society·Jung Hwan LeeDavid S Lawrence
Mar 23, 2004·Current Cancer Drug Targets·Johann Hofmann
Sep 30, 2004·International Journal of Pharmaceutics·J Vincent EdwardsI Kelman Cohen
Jul 26, 2005·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Kazuhiro IrieHajime Ohigashi
Aug 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Alessia PascaleAlessandro Quattrone
Nov 22, 2005·Bioorganic & Medicinal Chemistry·Jeewoo LeePeter M Blumberg
Jun 6, 2007·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Georg Martiny-Baron, Doriano Fabbro
Jun 8, 2007·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Alessia PascaleFiorenzo Battaini
Jun 22, 2007·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Fiorenzo Battaini, Daria Mochly-Rosen
Sep 14, 2007·The Biochemical Journal·Jenny BainPhilip Cohen
Dec 25, 2007·Regenerative Medicine·Chris Mason, Peter Dunnill
Aug 12, 2008·Current Drug Targets·P M BlumbergV E Marquez
Aug 19, 2008·Investigative Ophthalmology & Visual Science·Matthew D DavisUNKNOWN PKC-DRS2 Study Group
Oct 17, 2008·Physiological Reviews·Susan F Steinberg
May 15, 2009·Journal of Medicinal Chemistry·Gustav Boije af GennäsJari Yli-Kauhaluoma

❮ Previous
Next ❯

Citations

Nov 17, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bédis AmriSimona Collina
Sep 12, 2018·Platelets·Emmanuel AmpofoMichael D Menger

❮ Previous
Next ❯

Methods Mentioned

BETA
amputation

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

© 2022 Meta ULC. All rights reserved