Abstract
In this study, we used gene targeting in mice to identify the in vivo functions of PKD1. In addition to phenotypically characterizing the resulting knock-out animals, we also used mouse embryonic fibroblasts to investigate the associated signaling pathways in detail. This study is the first to use genetic deletion to reveal that PKD1 is a key regulator involved in determining the threshold of mitochondrial depolarization that leads to the production of reactive oxygen species. In addition, we also provide clear evidence that PKCδ is upstream of PKD1 in this process and acts as the activating kinase of PKD1. Therefore, our in vivo data indicate that PKD1 functions not only in the context of aging but also during nutrient deprivation, which occurs during specific phases of tumor growth.
References
Jul 13, 1995·Nature·A A BegD Baltimore
Mar 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·B Li, Q P Dou
May 23, 2001·The Journal of Biological Chemistry·A A MatassaM E Reyland
Nov 12, 2002·The EMBO Journal·Tracie A DeVriesMary E Reyland
Dec 31, 2002·The EMBO Journal·Peter Storz, Alex Toker
May 28, 2003·Biochemical and Biophysical Research Communications·Yong ShiHong Tang
Oct 3, 2003·The Journal of Biological Chemistry·Jeremy A YethonDavid W Andrews
Feb 10, 2004·The Journal of Biological Chemistry·Shyra J GardaiPeter M Henson
Mar 17, 2004·Molecular and Cellular Biology·Peter StorzAlex Toker
Aug 2, 2005·Biochimica Et Biophysica Acta·Laurent M DejeanKathleen W Kinnally
Sep 17, 2005·Molecular and Cellular Biology·Peter StorzAlex Toker
May 2, 2006·Molecular and Cellular Biology·Brooke C HarrisonTimothy A McKinsey
May 9, 2006·The Journal of Biological Chemistry·Meiguo Xin, Xingming Deng
Sep 7, 2007·The Journal of Biological Chemistry·Heike Döppler, Peter Storz
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jens FielitzEric N Olson
May 19, 2009·Cardiovascular Research·Dmitry B ZorovSteven J Sollott
Aug 8, 2009·Annual Review of Genetics·Chunxin Wang, Richard J Youle
Oct 27, 2010·PloS One·Qinhong WangXingming Deng
Jul 9, 2011·EMBO Reports·Ya Fu, Charles S Rubin
Dec 23, 2011·Molecular Pharmacology·Susan F Steinberg
Oct 16, 2012·The International Journal of Biochemistry & Cell Biology·Thibaud T RenaultStéphen Manon
Mar 28, 2013·International Journal of Cell Biology·Judith MichelsLorenzo Galluzzi
Citations
Jun 2, 2016·Cell Cycle·Tianzhou ZhangMichael Leitges
May 31, 2019·G3 : Genes - Genomes - Genetics·Dieter MaierAnette Preiss
Dec 24, 2017·Nature Communications·Julia Pose-UtrillaTeresa Iglesias
Apr 1, 2017·Frontiers in Oncology·Heike Döppler, Peter Storz
Jan 11, 2016·Cellular Microbiology·Hiroyasu TsutsukiMasatoshi Noda
Apr 8, 2020·Clinical and Experimental Pharmacology & Physiology·Haitao YuanJing Geng
Jul 7, 2017·Journal of Neurovirology·Wafa KammouniAlan C Jackson
Jun 2, 2018·Oxidative Medicine and Cellular Longevity·Mathias Cobbaut, Johan Van Lint
Oct 24, 2020·Trends in Pharmacological Sciences·Andrei-Florian StoicaSiim Pauklin
Aug 6, 2021·Oral Diseases·Yue DuXuedong Zhou