Place field expansion after focal MEC inactivations is consistent with loss of Fourier components and path integrator gain reduction

Proceedings of the National Academy of Sciences of the United States of America
Jake Ormond, Bruce L McNaughton

Abstract

Both hippocampal place fields and medial entorhinal cortex (MEC) grid fields increase in scale along the dorsoventral axis. Because the connections from MEC to hippocampus are topographically organized and divergent, it has been hypothesized that place fields are generated by a Fourier-like summation of inputs over a range of spatial scales. This hypothesis predicts that inactivation of dorsal MEC should cause place field expansion, whereas inactivation of ventral MEC should cause field contraction. Inactivation of dorsal MEC caused substantial expansion of place fields; however, as inactivations were made more ventrally, the effect diminished but never switched to contraction. Expansion was accompanied by proportional decreases in theta power, intrinsic oscillation frequencies, phase precession slopes, and firing rates. Our results are most consistent with the predicted loss of specific Fourier components coupled with a path integration gain reduction, which raises the overall place field scale and masks the contraction expected from ventral inactivations.

References

Apr 1, 1976·Experimental Neurology·J O'Keefe
May 14, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Francesco P BattagliaBruce L McNaughton
Aug 31, 2004·Science·Marianne FyhnMay-Britt Moser
Jun 21, 2005·Nature·Torkel HaftingEdvard I Moser
Sep 2, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alejandro TerrazasBruce L McNaughton
Jul 22, 2006·Nature Reviews. Neuroscience·Bruce L McNaughtonMay-Britt Moser
Nov 10, 2006·Hippocampus·Trygve SolstadGaute T Einevoll
Dec 29, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrew P MaurerBruce L McNaughton
Apr 17, 2008·The European Journal of Neuroscience·Tiffany Van CauterEtienne Save
Jul 5, 2008·Science·Kirsten Brun KjelstrupMay-Britt Moser
Nov 21, 2008·Hippocampus·Vegard Heimly BrunMay-Britt Moser
Feb 5, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sébastien RoyerGyörgy Buzsáki
May 7, 2010·Journal of Neurophysiology·Laura L ColginMay-Britt Moser
Apr 11, 2012·Journal of Neuroscience Methods·Richard KempterRobert Schmidt
Dec 12, 2012·Nature·Hanne StensolaEdvard I Moser
Jan 22, 2013·Nature Neuroscience·Jonathan J CoueyMenno P Witter
Jan 22, 2013·Nature Neuroscience·Tora BonnevieMay-Britt Moser
Apr 6, 2013·Science·Sheng-Jia ZhangEdvard I Moser
Jan 25, 2014·Science·Takashi KitamuraSusumu Tonegawa
May 30, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jorge JaramilloRichard Kempter
Dec 23, 2014·Nature Neuroscience·Yingxue WangEva Pastalkova

❮ Previous
Next ❯

Citations

Sep 4, 2015·ELife·Xue-Xin WeiVijay Balasubramanian
Apr 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·John L Kubie, Steven E Fox
Mar 30, 2016·Annual Review of Neuroscience·David C RowlandEdvard I Moser
Apr 10, 2017·Current Opinion in Neurobiology·Jorge Jaramillo, Richard Kempter
Jul 28, 2017·PloS One·Torsten NeherSen Cheng
Oct 27, 2017·Nature Neuroscience·Edvard I MoserBruce L McNaughton
Jan 18, 2018·Nature Neuroscience·Caitlin S MalloryLisa M Giocomo
Sep 4, 2018·Hippocampus·Geoffrey W DiehlJill K Leutgeb
Jan 9, 2018·PLoS Computational Biology·Lajos Vágó, Balázs B Ujfalussy
Sep 15, 2018·Hippocampus·Ulises Rodríguez-Domínguez, Jeremy B Caplan
May 22, 2018·Hippocampus·Blake S PorterDavid K Bilkey
Oct 13, 2019·The European Journal of Neuroscience·Laëtitia Chauvière
Jul 3, 2019·Frontiers in Cellular Neuroscience·Céline Drieu, Michaël Zugaro
May 12, 2017·Epilepsy Currents·Tristan ShumanPeyman Golshani
Mar 8, 2021·Neural Networks : the Official Journal of the International Neural Network Society·Adithya KrishnaChetan Singh Thakur
Aug 29, 2021·Nature Reviews. Neuroscience·Jon W RueckemannElizabeth A Buffalo
Oct 8, 2021·Neuron·Thibault CholvinMarlene Bartos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.