Place of biomarkers in the management of pulmonary infections

Revue des maladies respiratoires
M NeuvilleL Bouadma

Abstract

The management of acute lower respiratory tract infections and, in particular, the decision whether or not to commence antibiotic therapy, still remains difficult in the absence of reliable clinical or radiological criteria allowing confident distinction between bacterial and viral infections. Numerous biomarkers have been developed to help the clinician in his/her diagnostic and therapeutic approach, but the role and significance of each has not been clearly defined. Though procalcitonin (PCT) or C-reactive protein (CRP) seem equal in helping the clinician to decide whether to commence antibiotic therapy or not during the course of an exacerbation of asthma or chronic obstructive pulmonary disease (COPD), PCT is currently the most useful biomarker to distinguish sepsis from other causes of inflammation and to determine the bacterial or viral origin of a pneumonia. The ability of PCT to reduce the global exposure to antibiotics remains uncertain and the results of randomised trials are contradictory. Prescription algorithms involving PCT may be used without increased risk for patients even though clinical signs of severity remain important. Changes in PCT also have a prognostic value in identifying those patients with unfavoura...Continue Reading

References

May 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A BouchonM Colonna
Aug 14, 2001·American Journal of Respiratory and Critical Care Medicine·S HarbarthUNKNOWN Geneva Sepsis Network
Jul 20, 2002·International Journal of Antimicrobial Agents·E D CarrolC A Hart
Nov 14, 2003·The Pediatric Infectious Disease Journal·Cristina PratVicenç Ausina
Jan 30, 2004·The New England Journal of Medicine·Sébastien GibotPierre-Edouard Bollaert
Apr 14, 2004·Chest·Carlos M Luna
Apr 14, 2004·Chest·Jordi AlmirallUNKNOWN Community-Acquired Pneumonia Maresme Study Group
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Liliana SimonJacques Lacroix
Dec 17, 2004·The New England Journal of Medicine·Jennifer K PaiEric B Rimm
Feb 16, 2006·Intensive Care Medicine·Nicolas BoussekeyBenoit Guery
Apr 11, 2006·American Journal of Respiratory and Critical Care Medicine·Mirjam Christ-CrainBeat Müller
Jun 15, 2006·Wiener klinische Wochenschrift·Matjaz Jereb, Tadeja Kotar
Aug 9, 2006·Critical Care Clinics·Konrad ReinhartFrank M Brunkhorst
Aug 18, 2006·Critical Care Medicine·Jens Ulrik JensenMichael Tvede
Feb 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lionel A MandellUNKNOWN American Thoracic Society
Feb 24, 2007·The Lancet Infectious Diseases·Benjamin M P TangAnthony S McLean
Aug 29, 2007·Critical Care : the Official Journal of the Critical Care Forum·Luís CoelhoHenrique Sabino
Jan 17, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·José M PorcelManuel Vives
Oct 15, 2008·Archives of Internal Medicine·Matthias BrielMirjam Christ-Crain
Jun 25, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·U HohenthalP Kotilainen
Sep 10, 2009·JAMA : the Journal of the American Medical Association·Philipp SchuetzUNKNOWN ProHOSP Study Group
Sep 30, 1930·The Journal of Experimental Medicine·W S Tillett, T Francis
Feb 11, 2010·Critical Care : the Official Journal of the Critical Care Forum·Charalampos Pierrakos, Jean-Louis Vincent
Feb 27, 2010·The European Respiratory Journal·O BurkhardtT Welte
Apr 28, 2010·Journal of Clinical Microbiology·David N Gilbert
Oct 28, 2010·Current Opinion in HIV and AIDS·Kyle Strimbu, Jorge A Tavel
Apr 6, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David N Gilbert
Jul 9, 2011·The European Respiratory Journal·A SinganayagamJ D Chalmers
Feb 23, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·G N MatwiyoffM Daheshia
Jun 22, 2012·Seminars in Respiratory and Critical Care Medicine·Eric M Mortensen, Mark L Metersky

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.