Place of Interferon-γ Assay for Diagnosis of Congenital Toxoplasmosis

The Pediatric Infectious Disease Journal
Emmanuelle ChapeyFrançois Peyron

Abstract

The diagnosis of congenital toxoplasmosis relies mainly on serology. When results are doubtful, pediatricians have difficulties with respect to treatment. We report interferon-γ responses after the stimulation of blood by Toxoplasma gondii antigen in 17 infected infants and 80 infants free of infection. Sensitivity and specificity were 93.75% (95% confidence interval: 67%-99%) and 98.75% (95% confidence interval: 92%-99%), respectively.

References

Jan 1, 1993·Research in Immunology·J C Boothroyd, L D Sibley
Oct 1, 1996·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M LebechE Petersen
Mar 22, 2003·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A F FatoohiF Peyron
Apr 19, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rima McLeodUNKNOWN Toxoplasmosis Study Group
Nov 20, 2009·Journal of Clinical Microbiology·Emmanuelle ChapeyFrançois Peyron
Dec 3, 2009·The Pediatric Infectious Disease Journal·Muriel RabilloudFrançois Peyron
May 10, 2011·Trends in Parasitology·Reed Pifer, Felix Yarovinsky
Jan 31, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M WallonC Binquet

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Citations

May 6, 2016·Journal of Clinical Microbiology·Christelle Pomares, Jose G Montoya
Feb 8, 2020·Parasite : Journal De La Société Française De Parasitologie·Loïc SimonUNKNOWN Toxoplasma p35 Study Group
Oct 9, 2020·Scientific Reports·Thádia Evelyn de AraújoUNKNOWN UFMG Congenital Toxoplasmosis Brazilian Group UFMG-CTBG, beside the authors
Sep 10, 2020·The American Journal of Tropical Medicine and Hygiene·Marcelo RudzinskiJosé Raúl Oubiña

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