Place of Serology in the Diagnosis of Zoonotic Leishmaniases With a Focus on Visceral Leishmaniasis Due to Leishmania infantum.

Frontiers in Cellular and Infection Microbiology
Maude F LévêqueChristelle Pomares

Abstract

Leishmaniases are a group of parasitic diseases transmitted through the bite of female phlebotomine sandflies. Depending on the Leishmania species, the reservoirs can be humans (anthroponosis) or different animals (zoonosis). Zoonotic leishmaniasis present several clinical forms in function of the species involved: visceral leishmaniasis (VL), cutaneous leishmaniasis (CL), and muco-cutaneous leishmaniasis (MCL). The biological diagnosis is of utmost importance because the clinical features are not specific. In addition to parasitological and molecular biology (polymerase chain reaction, PCR) assays, serology is routinely used for the diagnosis of leishmaniasis. Indeed, although PCR is more sensitive than serological assays, its implementation is limited to referral laboratories and research centers. Therefore, serology is still a key element for their diagnosis. Here, we discuss the different serological assays available for the diagnosis of zoonotic leishmaniasis. We will review the enzyme-linked immunosorbent assay, immunofluorescence antibody test, immunochromatography test (ICT), direct agglutination test, and western blot as well as the different diagnostic strategies in function of the clinical form (VL, CL, and MCL). We ...Continue Reading

References

Sep 1, 1987·The American Journal of Tropical Medicine and Hygiene·J I dos SantosB Galvão-Castro
Apr 1, 1989·Memórias do Instituto Oswaldo Cruz·T G EvansR D Pearson
Nov 1, 1995·Transactions of the Royal Society of Tropical Medicine and Hygiene·P MartyJ Kubar
Sep 1, 1996·Diagnostic Microbiology and Infectious Disease·M MillesimoD Savoia
Oct 1, 1996·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·L NigroR Russo
Mar 6, 1998·Archives of Dermatology·P del GiudiceY Le Fichoux
Jul 12, 2002·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·O BrandonisioG Pastore
Dec 18, 2003·Annals of Tropical Medicine and Parasitology·M DeniauP Marty
Jul 11, 2006·Journal of Clinical Microbiology·Israel CruzJorge Alvar
Dec 28, 2007·Transactions of the Royal Society of Tropical Medicine and Hygiene·Mariana Junqueira PedrasAna Rabello
Feb 13, 2009·Transactions of the Royal Society of Tropical Medicine and Hygiene·A P T Barroso-FreitasK B F Marzochi
May 22, 2009·Transactions of the Royal Society of Tropical Medicine and Hygiene·Edward OliveiraAna Rabello
Sep 18, 2009·Journal of Clinical Microbiology·Bernard FerruaPierre Marty
Oct 26, 2010·Transactions of the Royal Society of Tropical Medicine and Hygiene·Tália S M de AssisAna Rabello
May 28, 2011·Transactions of the Royal Society of Tropical Medicine and Hygiene·Edward OliveiraAna Rabello
Sep 22, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M den BoerJ Alvar
Jun 5, 2012·Transactions of the Royal Society of Tropical Medicine and Hygiene·Christelle PomaresPierre Marty
Nov 14, 2012·Memórias do Instituto Oswaldo Cruz·Vanessa Peruhype-MagalhãesAna Rabello
Jan 18, 2013·The American Journal of Tropical Medicine and Hygiene·Viviana Pinedo-CancinoEufrosina Setsu Umezawa
Feb 6, 2013·Transactions of the Royal Society of Tropical Medicine and Hygiene·Edward OliveiraAna Rabello
Jul 10, 2013·The American Journal of Tropical Medicine and Hygiene·Gláucia Fernandes CotaAna Rabello
Sep 26, 2013·The American Journal of Tropical Medicine and Hygiene·Pantelis NtaisMaria Antoniou
Mar 4, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Om Prakash SinghShyam Sundar
Mar 13, 2014·The American Journal of Tropical Medicine and Hygiene·Beatriz Julieta CelesteHiro Goto
Jun 21, 2014·The Cochrane Database of Systematic Reviews·Marleen BoelaertSuman Rijal
Aug 15, 2014·Journal of Infection in Developing Countries·Ehab Kotb ElmahallawyJose Gutierrez Fernandez
Sep 2, 2014·Interdisciplinary Perspectives on Infectious Diseases·Bahador SarkariSamaneh Abdolahi Khabisi
Feb 18, 2016·Iranian Biomedical Journal·Mahin Farahmand, Hossein Nahrevanian
Mar 5, 2016·PLoS Neglected Tropical Diseases·Mohammad AkhoundiDenis Sereno
Apr 8, 2017·Veterinary Parasitology·Mariana Costa DuarteEduardo Antonio Ferraz Coelho

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Methods Mentioned

BETA
PCR
biopsy
Enzyme-Linked Immunosorbent Assay
ELISA

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