Placebo controlled double-blind study to test the efficacy of the aromatase inhibitor atamestane in patients with benign prostatic hyperplasia not requiring operation. The Schering 90.062 Study Group

The Journal of Urology
J C GingellU W Tunn

Abstract

We tested the theoretical concept that a selective decrease in estrogens has a beneficial therapeutic effect on established benign prostatic hyperplasia. In a double-blind study 160 patients from 14 centers were randomized between 2 groups to receive either placebo or the aromatase inhibitor atamestane (1-methyl-androsin-1,4 diene-3 17-dione, 400 mg. daily for 48 weeks). The aromatase inhibitor decreased the mean estradiol level by approximately 40% and estrone by 60%. The testosterone concentration increased by more than 40% and dihydrotestosterone increased to 30%. Analysis of clinical parameters showed no difference between placebo and atamestane. The counter regulatory increase in androgens may counterbalance any positive effect of the decrease in estrogens to preserve intraprostatic homeostasis.

References

Nov 1, 1979·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·H U Schweikert
Jul 1, 1983·The Journal of Clinical Endocrinology and Metabolism·J M DavidsonJ A Catania
Mar 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·U F HabenichtM F el Etreby
Mar 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·H U SchweikertW Horniger

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Citations

Oct 1, 2008·Prostate Cancer and Prostatic Diseases·J HammarstenD Mellström
Oct 19, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Gauri J SabnisAngela Brodie
May 3, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Yasukazu TakaseGeorges Pelletier
Jan 4, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Domenico PreziosoKeith Griffiths

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