PMID: 2117650Jul 1, 1990Paper

Placebo-controlled trial of misoprostol in cystic fibrosis

Journal of Pediatric Gastroenterology and Nutrition
P Robinson, P D Sly

Abstract

Seventeen children with cystic fibrosis were studied in a 6-week double-blind, placebo-controlled, crossover trial to determine the efficacy of misoprostol, 100 micrograms, four times a day, in improving fat absorption in patients already on pancreatic enzyme therapy. In those patients who had greater than 90% absorption on enzyme therapy alone, no further significant increase in absorption was achieved with misoprostol administration. Those patients who had absorption of less than 90% on standard enzyme therapy showed a significant improvement with misoprostol administration (p less than 0.01). One patient had a significant elevation in the eosinophil count during the period of misoprostol administration, but there were no significant changes in any other hematological or biochemical parameter. Misoprostol appears to be of benefit to those children with cystic fibrosis who have residual malabsorption on standard enzyme therapy.

Citations

Jan 27, 1998·Journal of Pediatric Gastroenterology and Nutrition·J C StevensS K Chong
Jul 27, 2002·Journal of Pediatric Gastroenterology and Nutrition·Mary Pat FranciscoDonald A Novak
Feb 24, 2001·Pharmacotherapy·N M DaviesF Jamali
Jun 25, 1998·Disability and Rehabilitation·J L Murphy, S A Wootton
Mar 18, 1999·Baillière's Clinical Gastroenterology·D Turck, L Michaud
Jul 26, 2006·Journal of the American Dietetic Association·Mary Sue BradyJohn C Stevens
Aug 23, 2016·The Cochrane Database of Systematic Reviews·Sze May Ng, Helen S Moore
Oct 20, 2010·The Medical Journal of Australia·James ToouliUNKNOWN Australasian Pancreatic Club
Apr 28, 2021·The Cochrane Database of Systematic Reviews·Sze May Ng, Helen S Moore

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