Placebo effect and therapeutic context: A challenge in clinical research

Medicina clínica
Antoni MorralXavier Bonfill

Abstract

When we apply a physical or pharmacological treatment, there are many things that may explain the clinical improvement experienced by a patient. The drugs or physical agents applied are important, but we must also add other elements in the context of the patient-therapist relationship. Scientific evidence has proven that the placebo effect exists. This is a true biopsychosocial phenomenon produced by the context in which an intervention is carried out. Biases aside, placebo and nocebo responses are changes in patients' symptoms, due to their participation at the therapeutic meeting, with its rituals, symbols and interactions. This multitude of signals inherent in any intervention, is perceived and interpreted by patients and can create positive or negative expectations.

Citations

Jan 29, 2019·Journal of Lower Genital Tract Disease·Alyson D GuilletCatherine M Leclair
Nov 11, 2020·BMJ Supportive & Palliative Care·Carlos CentenoAlvaro Sanz
Mar 13, 2021·European Child & Adolescent Psychiatry·Heidrun Lioba WunramOliver Fricke
Oct 12, 2021·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Clovis Varangot-ReilleJosé Casaña

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