PMID: 6408576Apr 1, 1983Paper

Placebo effect in surgery for Meniere's disease: three-year follow-up

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
J ThomsenN J Johnsen

Abstract

In 1981 we published the results of a double-blind, placebo-controlled study in which the efficacy of a regular endolymphatic sac mastoid shunt was compared with a purely placebo operation (mastoidectomy) in controlling the symptoms of 30 patients with typical Meniere's disease. Minor differences could be demonstrated between the shunt and the sham operation, but the greatest difference was between the preoperative and postoperative scores, and both groups improved significantly. It was concluded that the impact of the various endolymphatic sac shunts on the symptoms of patients with Meniere's disease is nonspecific, and that the 70% improvement in both groups was most likely caused by a placebo effect. At the time of the presentation, the results were based on a 1-year follow-up of all patients. As of January 1982 the patients had been followed for a minimum of 3 years. The 3-year results are the same as our results from the first year: no significant difference could be found between the two groups.

References

Sep 1, 1977·The Annals of Otology, Rhinology, and Laryngology·B R AlfordM Igarashi
Sep 1, 1979·Archives of Otolaryngology·K F Plantenga, G C Browning
Oct 1, 1977·The Laryngoscope·H E Maddox
Jun 1, 1973·The Journal of Laryngology and Otology·W F House, F D Owens
Jan 1, 1980·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·L B Jongkees
Jan 1, 1980·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·D E Brackmann, R G Anderson
Dec 1, 1981·Archives of Otolaryngology·I K Arenberg
Mar 1, 1981·The Journal of Laryngology and Otology·J Sadé

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Citations

Jan 8, 2005·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Nebil GöksuIsmet Bayramoğlu
Jun 22, 2006·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Isha TyagiRajan Syal
Aug 24, 2010·Current Opinion in Otolaryngology & Head and Neck Surgery·Aristides Sismanis
Mar 2, 2013·The Cochrane Database of Systematic Reviews·Bas PullensPeter Paul van Benthem
Jan 1, 1986·The Annals of Otology, Rhinology, and Laryngology·J ThomsenN J Johnsen
Aug 16, 2000·Clinical Otolaryngology and Allied Sciences·J J HomerN S Jones

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