Placebo responses in randomized trials of antiepileptic drugs

Epilepsy & Behavior : E&B
A B GuekhtE I Gusev

Abstract

This meta-analysis of published, randomized, controlled trials (RCTs) of antiepileptic drugs in adults with focal drug-resistant epilepsy was performed to estimate a mean placebo effect, to evaluate variability in placebo response rates, to investigate associations between placebo effect rates and study characteristics, and to determine whether there were changes in placebo response rates over recent years in RCTs (so-called "placebo drift"). One hundred ninety-eight potentially appropriate studies were identified after MEDLINE search and carefully reviewed. Twenty-seven RCTs (with 5662 randomized patients, including 1887 patients in placebo arms) were included in the meta-analysis. A random effects meta-analytic model estimated the pooled placebo response at 12.5% (95% CI: 10.03-14.94%). A statistically significant correlation between baseline median seizure frequency and placebo response rates was not observed. "Placebo drift" was not considered statistically significant.

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Citations

Jul 25, 2013·Pharmacology & Therapeutics·Danielle Murray, A Jon Stoessl
Feb 28, 2016·Epilepsy Research·Daniel M Goldenholz, Shira R Goldenholz
Feb 24, 2015·Epilepsy & Behavior : E&B·Gaetano ZaccaraDieter Schmidt
Mar 16, 2013·Epilepsy & Behavior : E&B·Dieter SchmidtKnut Stavem
Apr 6, 2017·European Journal of Clinical Pharmacology·Gaetano ZaccaraUmberto Benedetto
Jul 19, 2017·Expert Review of Clinical Pharmacology·Edoardo FerlazzoUmberto Aguglia
Sep 14, 2012·The Cochrane Database of Systematic Reviews·Gashirai K MbizvoAnthony G Marson
Sep 28, 2018·Neurology·Patricia ToleteOrrin Devinsky
Apr 4, 2017·Epilepsia·Joseph J TharayilDaniel M Goldenholz
Jan 1, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·N G NeznanovM Ya Kissin

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