Placebo therapy of benign prostatic hyperplasia: a 25-month study. Canadian PROSPECT Study Group

British Journal of Urology
J Curtis Nickel

Abstract

To analyse the efficacy, correlations and adverse-event profile of placebo therapy from the initial placebo run-in period to beyond 2 years of treatment. The effects of placebo therapy on prostate size, maximum urinary flow rate (Qmax) and symptoms were analysed, and adverse drug experiences documented, for a period of 25 months in 303 patients randomized to the placebo arm of a controlled trial evaluating finasteride in the treatment of BPH (the Canadian PROSPECT study). For all variables, the values during follow-up were significantly different from baseline (P < or = 0.001). Transrectal ultrasonography confirmed a progressive increase in prostate volume over 25 months (+8.4%) but Qmax improved for the first 5 months (to 1.4 mL/s over baseline) and remained 1.0 mL/s more than baseline at 25 months. The total symptom score improved by -2.9 points in the first 2 months on placebo and was ultimately 2.3 points below baseline at 25 months. The extent of the placebo response for symptoms (r=0.08, P=.180) and Qmax (r=0.04, P=0.550) was independent of age, but the response correlated with the initial severity of symptoms (r= -0.394, P < or = 0.001) and initial Qmax (r= -0.134, P=0.023). Patients with a prostate of < or = 40 mL had a...Continue Reading

References

Jan 1, 1992·The Prostate·J A BologneseE Stoner
Dec 24, 1955·Journal of the American Medical Association·H K BEECHER
Dec 26, 1955·Minerva medica·L SCHIAVETTI, F FERRARIS

❮ Previous
Next ❯

Citations

Jul 12, 2002·The Urologic Clinics of North America·Mark A Moyad
May 18, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Karin Meissner
May 2, 2001·Current Medical Research and Opinion·J Vale
Dec 18, 2007·The Journal of Urology·Kathleen Joy PropertUNKNOWN Interstitial Cystitis Clinical Trials Group
Apr 10, 2007·European Urology·Stephan MadersbacherGeorg Schatzl
Jan 25, 2005·International Journal of Urology : Official Journal of the Japanese Urological Association·Yiqing QiuXiaocao Shen
May 12, 2006·BJU International·Katalin HorváthImre Romics
Apr 25, 2007·European Journal of Pain : EJP·Ana MacedoMagí Farré
Apr 17, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·Kazuhiro ArakiHiroyoshi Suzuki
Jun 7, 2006·European Urology·Jules H Schagen van LeeuwenBart L H Bemelmans
Sep 24, 2013·Neuroscience and Biobehavioral Reviews·Jayne Jubb, Jozien M Bensing
Jun 17, 2016·Pain Management·Akiko OkifujiBradford D Hare
Mar 5, 2003·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Aaron E Katz
Mar 25, 2008·Journal of Medicinal Food·Wei ZhangSam Z Sun
May 20, 2008·The Journal of Urology·Steven A KaplanWilliam D Steers
Mar 22, 2019·The Journal of Dermatological Treatment·Ion G MotofeiSimona R Georgescu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.