Placebo versus low-dose ketamine infusion in addition to remifentanil target-controlled infusion for conscious sedation during oocyte retrieval: A double-blinded, randomised controlled trial

European Journal of Anaesthesiology
Hélène I MorueLuc A Barvais

Abstract

Currently, there is no gold standard for monitored anaesthesia care during oocyte retrieval. In our institution, the standard is a conscious sedation technique using a target-controlled infusion (TCI) of remifentanil, titrated to maintain a visual analogue pain score less than 30 mm. This protocol is well accepted by patients but is associated with frequent episodes of respiratory depression. The main objective of this study was to evaluate whether the addition of a continuous intravenous infusion of ketamine could reduce these episodes. Controlled, randomised, prospective, double-blinded study. The current study was conducted in a tertiary-level hospital in Brussels (Belgium) from December 2013 to June 2014. Of the 132 women undergoing oocyte retrieval included, 121 completed the study. After randomisation, patients received either a ketamine infusion (40 μg kg min over 5 min followed by 2.5 μg kg min) or a 0.9% saline infusion in addition to the variable remifentanil TCI. The primary outcome was the number of respiratory depression episodes. Effect site target remifentanil concentrations, side effects, pain score, patient satisfaction and incidence of pregnancy were also recorded. No significant difference in the incidence of...Continue Reading

References

Apr 1, 1990·Journal of in Vitro Fertilization and Embryo Transfer : IVF·S S RamsewakI D Cooke
Jan 1, 1981·British Journal of Anaesthesia·J A Clements, W S Nimmo
Mar 1, 1997·Journal of Assisted Reproduction and Genetics·E C DitkoffM V Sauer
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Jul 19, 2003·Human Fertility : Journal of the British Fertility Society·Nicholas M ElkingtonUmesh Acharya
Mar 3, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Nikos F VlahosNikolaos Vitoratos
Nov 27, 2014·Current Neuropharmacology·Gianluca SerafiniMario Amore

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Citations

Feb 26, 2021·Current Pain and Headache Reports·Tiffany S Moon, Katelynn M Smith

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