Placenta-based therapies for the treatment of epidermolysis bullosa

Cytotherapy
Christopher Nevala-PlagemannJakub Tolar

Abstract

Recessive dystrophic epidermolysis bullosa (RDEB) is a severe blistering skin disease caused by mutations in the COL7A1 gene. These mutations lead to decreased or absent levels of collagen VII at the dermal-epidermal junction. Over the past decade, significant progress has been made in the treatment of RDEB, including the use of hematopoietic cell transplantation, but a cure has been elusive. Patients still experience life-limiting and life-threatening complications as a result of painful and debilitating wounds. The continued suffering of these patients drives the need to improve existing therapies and develop new ones. In this Review, we will discuss how recent advances in placenta-based, umbilical cord blood-based and amniotic membrane-based therapies may play a role in the both the current and future treatment of RDEB.

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Citations

Nov 9, 2015·Best Practice & Research. Clinical Obstetrics & Gynaecology·Eleni Antoniadou, Anna L David
Aug 1, 2015·Molecular Therapy : the Journal of the American Society of Gene Therapy·Marketa Tolarova, Jakub Tolar
Aug 15, 2018·Sociology of Health & Illness·Julie KentSally Dowling
Mar 31, 2017·Intractable & Rare Diseases Research·Ellie Rashidghamat, John A McGrath

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